We set out to investigate the mechanism(s) of hemodialysis (HD)-induced hyperthermia. We found that the increase in rectal temperature (T) during HD exceeds that due to circadian changes observed during the day off HD (0.48 versus 0.15 °C; p < 0.05). To assess the role of heat transfer from dialysate to blood, we increased dialysate T from 34 to 38 °C and observed a proportional increase in rectal T (r = 0.75). However, even when heat transfer from dialysate to blood was totally prevented rectal T still rose by 0.67 ± 0.41 (SD) °C. To assess if endogenous pyrogen could account for this increase in rectal T we performed HD with sterile dialysate (to exclude the potential contamination of standard dialysate) and during intravenous aspirin infusion (1 g before HD followed by continuous infusion of 4 mg/min) to block the effect of endogenous pyrogen on the thermoregulatory center. Both these procedures failed to prevent the increase in rectal T observed in the standard control HD. In conclusion, HD hyperthermia is not accounted for by circadian variations in body T, or by passive heat transfer from dialysate to blood. We failed to obtain indirect evidence to support the hypothesis that dialysis hyperthermia is caused by endogenous pyrogen production.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.