Maintenance dialysis (MD) patients frequently present mild to severe malnutrition. Food intake is often reduced by anorexia. A state of persistant catabolism may be caused by chronic acidosis, resistance to anabolic factors such as growth hormone, insulin and insulin-like growth factor-1. Losses of nutrients including glucose, amino acids and vitamins occur during the dialysis treatment, and negative nitrogen balance has been reported during hemodialysis. Intradialytic parenteral nutrition containing lipids, glucose and amino acids has been administered to malnourished MD patients when oral supplements have failed to improve their nutritional status. Amino acid infusion into the peritoneal cavity induces positive nitrogen balance in malnourished continuous ambulatory peritoneal dialysis patients. Anabolism has been observed during administration of recombinant growth hormone and insulin-like growth factor-1 in malnourished MD patients. In the fight against catabolic events, an increase in nutrient intake or delivery by dialysis and promotion of anabolism simultaneously may be prerequisite for correcting malnutrition in MD patients.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.