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Book Chapter
Book Chapter
Series: Endocrine Development
Volume: 13
Published: 05 June 2008
10.1159/000134751
EISBN: 978-3-8055-8581-1
... facilitates the rapid influx ofcholesterol into mitochondria, where P450scc resides. Qualitative regulation, determining the class ofsteroid produced, is principally determined by P450c17. In the absence of P450c17 in the zona glomerulosa,C21 deoxy steroids are produced, leading to the mineralocorticoid...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321209
EISBN: 978-3-8055-9644-2
... and pubic hair, usually about age 8. The physiologic correlate of adrenarche is the development of the adrenal zona reticularis, which has many of the biochemical properties of the fetal adrenal. Recentstudies have shown that adrenarche is not an abrupt and ‘signaled’ process occurring in mid childhood...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 88
Published: 11 August 2005
10.1159/000087818
EISBN: 978-3-318-01233-0
... immunologically characterized sperm proteins - as cognate antigens ofnaturally occurring ASA or of artificially produced antibodies - are quoted with respect todifferent sperm functions in the course of fertilization: cervix mucus penetration, zona binding,zona penetration, oolemma binding, and pronucleus...
Book Chapter
Series: Endocrine Development
Volume: 13
Published: 05 June 2008
10.1159/000134765
EISBN: 978-3-8055-8581-1
.../17,20-lyasecytochrome P450 (P450c17) are necessary for DHEA production and are differentially regulated duringadrenal development. Production of DHEA and DS occurs in the zona reticularis (ZR) of adults and the fetalzone of fetal primate adrenal glands, which is the primary substrate for maternal...
Book Chapter
Series: Endocrine Development
Volume: 13
Published: 05 June 2008
10.1159/000134830
EISBN: 978-3-8055-8581-1
... Abstract Adrenal aldosterone production, the major regulator of salt and water retention, is discussed with respectto hypertensive diseases. Physiological aldosterone production is tightly regulated, either stimulated orinhibited, in the adrenal zona glomerulosa by both circulating factors...
Book Chapter
Series: Endocrine Development
Volume: 13
Published: 05 June 2008
10.1159/000134831
EISBN: 978-3-8055-8581-1
... female rhesus monkeys.Overall, our findings suggest that differentiation of the monkey adrenal cortex in a hyperandrogenic fetalenvironment may permanently upregulate adult adrenal androgen biosynthesis through specific elevationof 17,20-lyase activity in the zona fasciculata-reticularis. As adult...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 88
Published: 11 August 2005
10.1159/000087823
EISBN: 978-3-318-01233-0
... for the establishment and maintenance of pregnancy. Immunization studies in variousanimal models including non-human primates with zona pellucida (ZP) glycoproteins havedemonstrated curtailment of fertility. To circumvent the ovarian pathology often observed followingimmunization with ZP glycoproteins, synthetic...
Book Chapter
Series: Endocrine Development
Volume: 8
Published: 15 February 2005
10.1159/000084092
EISBN: 978-3-318-01178-4
... secretionfrom the adrenal zona reticularis and this may contribute to disorders of hyperandrogenismand hyperinsulinemia before and after puberty. Precocious pubarche, the clinical manifestationof adrenal hyperandrogenism prepuberty, in girls is predictive of polycystic ovarysyndrome, and is also associated...
Book Chapter
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/000363612
EISBN: 978-3-318-02559-0
... enzyme represents the qualitative regulator determining the class of produced steroid hormone. In the zona glomerulosa, absence of CYP17A1 leads to mineralocorticoid synthesis. In contrast, isolated 17α-hydroxylase activity of CYP17A1 results in the synthesis of glucocorticoids in the zona fasciculata...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321211
EISBN: 978-3-8055-9644-2
... to differentiate into adult zones, including zona fasciculata and zona glomerulosa. Later on, the zona reticularis develops during a process called adrenarche and gives rise to an increase in adrenal androgen secretion [ 1 ]. Three main structural characteristics facilitate the interaction between...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321229
EISBN: 978-3-8055-9644-2
... of hypertension. CYP11B1 and CYP11B2 CYP11B2 and CYP11B1 are highly homologous genes that lie on chromosome 8 in man; they share >95% homology in nucleotide sequence and in primary protein structure [ 10 ]. CYP11B2 encodes aldosterone synthase; it is expressed in zona glomerulosa of the adrenal...
Book Chapter
Series: Endocrine Development
Volume: 22
Published: 30 July 2012
10.1159/000326625
EISBN: 978-3-8055-9337-3
.... The adrenal cortex consists of 3 zones (zona glomerulosa, zona reticularis and zona fasciculata). Their development depends on adrenocorticoptropic hormone (ACTH). The zona fasciculata and reticularis of the adrenal cortex produce cortisol and androgens. The zona glomerulosa of the adrenal medulla secretes...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 43
Published: 12 June 2014
EISBN: 978-3-318-02674-0
... MJ: Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculate-like tumors. J Clin Endocrinol Metab 2012;97:E819-E829. 12. Zennaro M-C, Jeunemaitre X, Boulkroun S: Integrating genetics...
Book
Book Cover Image
Series: Endocrine Development
Volume: 13
Published: 05 June 2008
10.1159/isbn.978-3-8055-8581-1
EISBN: 978-3-8055-8581-1
Book
Book Cover Image
Published: 02 March 2000
10.1159/isbn.978-3-318-00453-3
EISBN: 978-3-318-00453-3
Book Chapter
Series: Progress in Neurological Surgery
Volume: 24
Published: 24 March 2011
10.1159/000323052
EISBN: 978-3-8055-9489-9
... stimulation sites seem to be very well- established, as in Parkinson disease (nucleus ventralis intermedius of the thalamus – Vim, internal part of globus pallidus – GPi, sub- thalamic nucleus – STN and zona incerta), dystonia (GPi), tremor (Vim, zona incerta), choreoathetosis (Vim, GPi, zona incerta, nucleus...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 43
Published: 12 June 2014
10.1159/000360870
EISBN: 978-3-318-02674-0
..., is expressed in the zona fasciculata and encodes aldosterone synthase. The chimeric gene reflects misalignment at recombination following meiosis, possible in that the genes encoding the two enzymes are located in tandem 38 kb apart on 8q24.3. Hypertension is often of early onset, and subjects are prone...
Book
Book Cover Image
Published: 01 June 1993
10.1159/isbn.978-3-318-04378-5
EISBN: 978-3-318-04378-5
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 42
Published: 29 November 2016
EISBN: 978-3-318-05946-5
... comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV cohort study. Clin Infect Dis 2014;59:1787-1797. 21. Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, Garlassi E, Berti A, Rossi E, Roverato A, Palella F: Premature age-related comorbidities among HIV-infected...