... Abstract Since its initial description in 1851, Munchausen syndrome has been widely used interchangeably with factitious disorder. Nevertheless, this syndrome is only one form of factitious disorder that is both severe and chronic. The syndrome was named after Karl Friedrich Hieronymus, Baron...

... is involved in most DR lesions, and, thus, its proper visualization is crucial for the screening, diagnosis, monitoring, treatment, and prognosis of DR. To expand the field of view, wide-field and ultra-wide-field imaging have been developed, allowing images up to 200° of retinal surface in one single photo...

... and the two general models of providing it (via departments and teams) are also represented in several other hospital-wide interventions to improve care for hospitalized frail elderly inpatients, e.g. the Hospital Elder Life Program and the Nurses Improving Care for Health System Elders program [ 26...

... Abstract Genome-wide association studies (GWAS) provide important insights into type 2 diabetes (T2D) pathogenesis. The common variant GWAS approach enables capture of disease risk-associated sequence variation on a previously unachievable scale, implicating roughly 70 genomic regions in T2D...

... Abstract Genome-wide association studies (GWAS) of patients with type 2 diabetes (T2D) and unaffected controls (case-control studies) have been hugely successful in identifying T2D risk loci. In the first 2 years of GWAS, over 13 loci were found to associate with T2D risk, 4-fold more than...

... Abstract Genome-wide association studies (GWAS) of obesity-related traits are defining the genetic architecture of obesity, revealing genes and mechanisms for disease. GWAS have been performed for several measures of obesity including body mass index (BMI), body fat distribution, and fat mass...

... Abstract A wide-angle viewing system offers a panoramic view of the surgical field and also improves the safety and efficacy of the vitreoretinal surgical procedure. Surgeons can easily observe the fundus in almost the whole area and evaluate the retinal pathologies through the panoramic view...

..., together with the known familial aggregation of disease, suggests an inherited mechanism. Recently three genome-wide association studies (GWAS) of IgAN have identified seven susceptibility loci, providing initial insight into the genetic architecture of this trait. While genetic studies of complex traits...

... Abstract Despite the high heritability of human growth traits, until recently little was known about the underlying genes and genetic variants which explain normal variation of growth. In the past few years, genome-wide association studies have successfully identified hundreds of genetic...

... capability and reductions in cost, coupled with large collaborative population groups are enabling exponential advances in our understanding of human genetic variation. Genome-wide association studies (GWAS) are greatly increasing our understanding of the genetic basis of human disease, especially complex...

... became evident, other regions of the chromosomes, such as telomeres, were targeted by FISH or other methods to try to increase the diagnostic yield of cytogenetic testing. The development of new genome-wide technologies has allowed the resolution of cytogenetic tests to reach an unparalleled level...

... Abstract Two novel methods for genome wide selection (GWS) were examined for predicting the genetic merit of animals using SNP information alone. A panel of 1,546 dairy bulls with reliable EBVs was genotyped for 15,380 SNPs that spanned the whole bovine genome. Two complexity reduction methods...

... candidategene approaches have not been tremendously successful in identifying relevant genetic contributorsto obesity, except PPAR , the advent of genome-wide strategies has recently revealed novel and unexpectedgenetic factors with strong associations with obesity and/or diabetes, i.e. FTO, TCF7L2, INSIG2...