... produce gastrointestinalsymptoms and increased production of pro-inflammatory cytokines. Such problems may bea warning sign (‘canary in the coal mine’) for the onset of exertional heat stroke. Failure to heed sucha warning may culminate in problems indicative of exertional heat stroke such as circulatory...

... chemical hazards in thefood chain will be presented with an emphasis on the use of early warning to identifypotential new contaminants. Early warning is also a means of prevention, anticipatingfood safety concerns before they become issues to manage. Current best managementpractices including Hazard...

...-receptor antagonists, and particularly tolvaptan, have been investigated as a pharmacological approach for the management of hypervolemic hyponatremia in cirrhosis. However, existing information on its efficacy in cirrhosis is still scarce and a recent warning has been raised about their potential role...

... through tattooing or introduced by tattooing as a primary sensitization. The use of intralesional corticoid, antihistamines, and immunosuppressive medicines is discussed. A warning against the use of lactic acid and other caustic chemicals for tattoo removal is given, since such chemicals and commercial...

... by smoke-free areas, bans on all forms of advertising, promotion and sponsorship, optimum tobacco taxation, packet warning labels and cessation programmes at the highest, optimal level. There has been an increase in global funding for tobacco control, yet national funding remains woefully inadequate...

... meters, or central laboratory. Blood gas analyzers are considered the best compromise between accuracy and practicality. Real-time continuous glucose monitoring (RTCGM) offers interesting possibilities: automatic measurement of large numbers of BG values and alarms that warn whenever ‘outlier' values...

... the Black Box warning issued in the United States. Poor compliance may explain the failure to respond to therapy, and contact dermatitis from topical application of emollients and medications may mimic AD, erroneously suggesting recalcitrance. For patients with severe AD, administration of systemic...

... in the blood of most patients with septic shock remains enigmatic and a subject of considerable controversy. LPS is the most prominent ‘alarm molecule’ sensed by the host’s early warning system of innate immunity presaging the threat of invasion of the internal milieu by Gram-negative bacterial pathogens...

...’. Stendhal’s TIAs a few months before his fatal stroke constitute the first historical report of the warning nature of TIAs, which would be emphasized only over 100 years later. Henri-Marie Beyle was born in Grenoble, France, in 1783, and he died 59 years later in Paris from what was then called...

... for animal health, animalwelfare, food supplies, economies and biodiversity. Intervention strategies should focus foremost onthe surveillance of LPAI and HPAI viruses in animals and humans, to provide early warning systems andvirus repositories that will allow the timely establishment of seed viruses...

.... Such clonal aberrationsare a very strong clinical warning sign. All available evidence suggests that the finding ofany chromosomal abnormality in bone marrow cells, especially abnormalities involvingchromosomes 3 and 7, warrant very close clinical follow-up, as they may signal the developmentof MDS or AML. ...

... function may be unableto detect important warning signs such as gas leaks, volatile chemical fumes and fires andtherefore place themselves and coworkers at an increased risk for serious injury or death. ...

... if it occurs suddenly and without warning, is an extreme test of coping capacities. Study of parents of leukemic patients elucidated reactions similar to those observed in studies of burn and polio patients. Coping strategies useful to persons of various ages, both sexes, and different socioeconomic...

... people from tobacco smoke • Offering help to quit tobacco use • Warning about the dangers of tobacco • Enforcing bans on tobacco advertising, promotion and sponsorship • Raising taxes on tobacco MPOWER has now become the backbone of tobacco control legislation [ 8 , 9 ] (see also...

... for industry: warnings and precautions, contraindications, and boxed warning sections of labeling for human prescription drug and biological products — content and format: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm075096.pdf (accessed December 20,2010) 23...

... rule on the requirements for prescribing information for drug and biological products, January 18,2006, summary: http://www.fda.gov/Drugs/GuidanceComplianceRegulatory Information/LawsActsandRules/ucm085169.htm (accessed November 9,2010) 22. Guidance for industry: warnings and precautions...