Search Results for viral

... position of phospholipids) owing to putative viral infectious inhibition of the first long-chain polyunsaturated fatty acid biosynthetic step catalyzed by delta-6-desaturase [ 33 , 34 ]. DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), has recently been...

... source of potential competitors of viral glycan receptors, which mimic the structures of blood group-active O-glycans. For example, the trisaccharide 2′-fucosyllactose (2′FL) is able to block norovirus binding quite efficiently [ 9 , 10 ], and it has reached market approval as a save food additive...

..., other anogenital cancers, oropharyngeal cancers, and cutaneous malignancies in susceptible individuals, causing an estimated 5.2% of virally associated cancers worldwide. HPVs are small, double-stranded DNA viruses of the Papillomaviridae family; to date 150 genotypes have been characterized...

..., while patients infected as adults have a risk of 2–10%. The treatment of chronic hepatitis B should be assessed case by case, depending on viral load, biochemical parameters and inflammation within the liver. Infections due to hepatitis C virus occur most often without symptoms and most patients...

... Abstract Non-viral pathogens affecting liver leading on to parenchymal or biliary damage is uncommon, however mild to moderate hepatic dysfunction is not uncommon in bacteremic patients. The etiology of non-viral infection of the liver varies with geographical location as parasitic infestations...

... lesions of patients with PAH-HIV [ 19 ]. However, viral proteins and their interactions with molecular partners in the infected host may promote apoptosis, growth, and proliferation. Excessive production of endothelin-1 (ET-1) has been implicated in endothelial cell dysfunction and in the pathogenesis...

... Abstract Much attention has been focused on the elucidation of mechanisms whereby atopic dermatitis (AD) skin lesions are especially susceptible to certain viral infections, such as herpes simplex virus (HSV). Although one of the most likely hypotheses is that the primary defect...

... Abstract The lack of effective treatments for many forms of hearing and vestibular disorders has produced interest in virally mediated gene therapies. However, to develop a gene therapy strategy that would successfully treat inner ear disorders, appropriate viral vectors capable of transfecting...

... Abstract Many factors play into the complexity of viral pathogenesis. Understanding viral pathogenesis is key to developing vaccines and treatments for viral diseases. One emerging area of research is proteomics, which is the study of the protein complement and functions of the genome. Many...

... Abstract Bovine viral diarrhoea viruses (BVDV) are significant pathogens of cattle worldwide. These viruses exist in both non-cytopathic and cytopathic biotypes. Non-cytopathic BVDV can establish persistent lifelong infections in cattle and are a frequent contaminant of biological reagents...

... this possibility, we have generated transgenic mice that express RNAi molecules targeting a conserved region of the influenza A NP gene and are testing these mice for resistance to influenza infection. Transgenes were initially developed that express short hairpin RNAs (shRNAs) targeting multiple influenza A viral...

... will discuss the pathogenesisof Kaposi sarcoma and KSHV-induced lymphoma, including primary effusion lymphoma and multicentricCastleman disease. We will also provide a brief introduction to the virus itself. We particularly focus onthe viral gene expression pattern together with the current animal models...