... some speculations that HyU treatment could stop the progression of CRF modifying the natural history of the diseases. So there will be new clinical trials with old and new medication and metabolic procedure to maintain a very low blood levels in the unknown uremic toxin know as uric acid which seems...

... Abstract In patients with chronic kidney disease (CKD), uremic toxins constitute a specific nontraditional risk factor. Research in this field started in the early 1990s, and a growing body of preclinical and epidemiological evidence suggests that elevated levels of uremic toxins are associated...

... and the malnutrition, inflammation, and atherosclerosis syndrome, induces and reignites processes leading to PEW in a number of ways including stimulation of both direct and indirect mechanisms of muscle proteolysis. Similar to other chronic diseases, inflammation in the uremic milieu is the consequence of multiple...

.... Dysregulation of these same miRNAs was observed in the serum of CKD, hemodialyzed, and kidney transplant recipients. We also demonstrated correlations between serum miRNAs and uremic toxins. We therefore suggest that miR-126, miR-143, miR-145, and miR-223 are potential biomarkers of vascular calcification...

... Abstract Uremic itch is a frequent and sometimes very tormenting symptom in patients with advanced or end-stage renal failure, with a strong negative impact on the quality of life. According to a representative study, the point prevalence of chronic itch is 25% in hemodialysis patients but may...

... disease is an example of complex disease in which the phenotype arisesfrom a combination of environmental and heritable factors. Evidence suggests that the contributionmade by the environment may be mediated via modifications of the epigenome. Inthe uremic milieu, several features such as inflammation...

... Abstract The uremic syndrome is defined by a complex clinical picture, characterized by thedysfunction of most organs which are affected by the retention of multiple solutes. Recentresearch has helped to unravel the pathophysiology and to identify several as yet unknownresponsible compounds...

... Abstract Kidney failure leads to the uremic syndrome that is the clinical expression of the malfunctionof vital organs due to the accumulation of uremic toxins, which are normally clearedby the kidneys. Progressively more uremic retention solutes have been identified and theirpotential toxicity...

... Abstract The uremic syndrome is characterised by the retention of a host of compounds that inhealthy subjects are secreted by the kidneys into normal urine. These compounds disturbmany physiologic functions, resulting in toxicity. Many of the responsible compoundsremain unknown, however...