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Book
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517671
EISBN: 978-3-318-06937-2
... of disease understanding. We will introduce concepts of primary and secondary prevention and explore the ways in which the application of different epidemiological study designs has contributed to the knowledge and understanding of kidney diseases. We will discuss the strengths and weaknesses of different...
Book
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494901
EISBN: 978-3-318-06471-1
... of the steroid-converting enzymes in human adipose tissues. J Steroid Biochem Mol Biol 2015;147:56–69. 25. O’Reilly MW, House PJ, Tomlinson JW: Understanding androgen action in adipose tissue. J Steroid Biochem Mol Biol 2014;143:277–284. 26. Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500391
EISBN: 978-3-318-06540-4
... methodologies; nevertheless, these approaches offer a limited understanding of the interacting genes and products that drive the complex pathogen-host system. The emergence of large-scale omics datasets provides an understanding of the complexity of pathogen-host interactions. In this chapter, we have...
Book Chapter
Book Chapter
Book
Book Cover Image
Series: Karger eBooks Non-Series Collection
Published: 14 May 2018
10.1159/isbn.978-3-318-06380-6
EISBN: 978-3-318-06380-6
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 118
Published: 24 April 2018
10.1159/000484341
EISBN: 978-3-318-06253-3
... that the “devil is in the detail” when it comes to the implementation of large-scale nutrition interventions. The case study also shows that an understanding of the details of the implementation mechanisms of nutrition programs is essential for designing governance reform options that have good prospects...
Book Chapter
Series: Medicine and Sport Science
Volume: 61
Published: 16 June 2016
10.1159/000445237
EISBN: 978-3-318-03011-2
... influenced by multiple different types of DNA variants, both rare and common. This introductory review will aim to equip the reader with the necessary vocabulary to understand and interpret genetic studies targeted to sport performance and sport-related injury. Table 1 Key terms in human genetics...
Book Chapter
Book Chapter
Series: Monographs in Human Genetics
Volume: 20
Published: 26 April 2016
10.1159/000444570
EISBN: 978-3-318-05856-7
... in a mouse model for human deafness is an appropriate and necessary first step in the search for a cure for human disease. Viral Vectors With an understanding of the genes used in cochlear gene therapy, it is important to consider the vector as it has a direct and essential impact upon the successful...
Book
Book Cover Image
Published: 01 July 2015
10.1159/isbn.978-3-318-05459-0
EISBN: 978-3-318-05459-0
Book Chapter
Series: Advances in Psychosomatic Medicine
Volume: 34
Published: 24 March 2015
10.1159/000369043
EISBN: 978-3-318-02967-3
... but also reaffirm psychosomatic concepts, as suggested decades ago by Weiner [ 16 , 17 ]. As medicine evolved to a true science that utilized the scientific method to understand pathology, diagnosis and treatment, many physicians abandoned psychosocial factors and focused primarily on the objective...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 80
Published: 15 December 2014
10.1159/000360356
EISBN: 978-3-318-02672-6
... Abstract A comprehensive understanding of the factors influencing women's dietary choices is central to motivating positive dietary behavior before, during and after pregnancy. Findings are synthesized from 34 studies which assessed modifiable individual and environmental factors influencing...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362474
EISBN: 978-3-318-02700-6
... that it is a hibernating animal. Nevertheless, the mouse does provide a valuable tool for understanding human diabetes and obesity, as many processes are well conserved. Indeed, mice carrying gain-of-function mutations in the KCNJ11 gene which encodes the Kir6.2 subunit of the K ATP channel recapitulate many...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362476
EISBN: 978-3-318-02700-6
... Abstract The high worldwide prevalence of type 2 diabetes (T2D) is driving major efforts to understand the genetic basis of the disorder, with the expectation that this will increase our understanding of disease biology and consequently lead to improved patient stratification, disease...
Book
Book Cover Image
Series: Endocrine Development
Volume: 27
Published: 15 September 2014
10.1159/isbn.978-3-318-02559-0
EISBN: 978-3-318-02559-0
Book Chapter
Series: Monographs in Oral Science
Volume: 25
Published: 24 June 2014
10.1159/000359943
EISBN: 978-3-318-02553-8
... of a product, strongly influence erosion in vivo. The net effect of the solution factors determines the overall erosive potential of different products. Prospects for remineralization of erosive lesions are evaluated. Our objective is to provide a model for the chemical understanding of dental erosion...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 28
Published: 17 June 2014
10.1159/000358763
EISBN: 978-3-318-02649-8
... symptoms. Understanding the physical consequences of a concussive injury has proven to be an arduous if not elusive task. Symptoms varying anywhere from minutes to months or even years can be present in concussed patients despite any apparent physical injury. Reconciling the neural effects...