... such as epithelial-to-mesenchymal transition (EMT) or endothelial-to-mesenchymal transition (EndoMT). Summary: We have reported that UA-induced EMT of cultured renal tubular cells, which was blocked by the organic anion transport inhibitor, probenecid. UA increased the expression of snail and slug...

... Abstract Podocytes hold a strategic position in the regulation of the trafficking between the glomerular and tubular compartments. Defects in the expression of podocytic proteins or injury to podocytes may result in heavy proteinuria, glomerulosclerosis, and loss of kidney function. The process...

... Abstract IgA nephropathy (IgAN) is characterized by mesangial deposition of pathogenic polymeric IgA1 with rare deposits in the tubular epithelial cells (TEC). Recently, a novel mechanism involving a glomerulopodocytictubular cross-talk in the development of tubulointerstitial damage in IgAN...

... Abstract Injury to the interstitium of the kidney is regarded as a common pathway leading to end-stage renal insufficiency, regardless of etiology. Tubular interstitial nephritis is characterized histologically by inflammatory changes in the tubulointerstitial compartment, such as interstitial...

... renal vasoconstriction and, finally, experimental studies suggest that immune-mediated injury may be a more likely cause of tubular cell dysfunction than ischemia. These lines of evidence suggest that the pathogenesis of AKI is complex, does not simply involve ischemia, and may differ according...

... with proximal tubular functional abnormalities, such asFanconi syndrome. These proximal tubule alterations often progress to a severe tubulointerstitialkidney disease, the most common type of kidney involvement responsible for endstagerenal failure seen in myeloma patients. ...