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Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 43
Published: 16 October 2018
10.1159/000490450
EISBN: 978-3-318-06394-3
... Abstract In this essay, we propose an association between Franz Kafka's novel, The Trial , and phenomenological and neurobiological processes in schizophrenia. We begin by presenting a summary of the plot, pointing to some of its remarkable literary aspects. We next compare the mental...
Book Chapter
Series: Monographs in Oral Science
Volume: 27
Published: 24 September 2018
10.1159/000487841
EISBN: 978-3-318-06369-1
... Abstract Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness. This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical...
Book Chapter
Series: Current Problems in Dermatology
Volume: 53
Published: 13 November 2017
10.1159/000478074
EISBN: 978-3-318-06101-7
... Abstract Physicians rely on safety and efficacy data from pivotal trials to guide treatment decisions and manage patients. Even with robust clinical trial data, there remain questions regarding rare safety events and generalizability. Registries complement clinical trials. By evaluating...
Book Chapter
Series: Developments in Ophthalmology
Volume: 60
Published: 24 April 2017
10.1159/000459707
EISBN: 978-3-318-06042-3
... Abstract Two critical questions one must answer as one applies the results of a clinical trial to clinical practice are: (1) Regardless of whether the trial result is likely to be replicated or reproduced in a second large-scale trial, are the results likely to be reproduced in one's practice...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 39
Published: 03 August 2016
10.1159/000445408
EISBN: 978-3-318-05865-9
... Abstract Background: According to the Directive 2001/20/EC of the European Union, a clinical trial is any investigation in human subjects intended to (1) discover or verify the clinical, pharmacological, and/or other pharmacodynamic effects of one or more investigational medicinal product(s...
Book Chapter
Series: Contributions to Nephrology
Volume: 181
Published: 13 May 2013
10.1159/000348475
EISBN: 978-3-318-02390-9
... decline during antihypertensive and antiproteinuric therapy over an observation period of at least 6 months (1B) or in patients with severe, disabling, or life-threatening symptoms related to their NS (1C) [ 7 ]. Although a number of randomized, controlled trials of different immunosuppressive agents...
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315922
EISBN: 978-3-8055-9485-1
...-negative or mixed pathogens, and is likely associated with high endotoxin levels. Therefore, it represents a condition in which endotoxin-targeted therapy may be of particular benefit [ 3 ]. The EUPHAS study, a randomized controlled trial in a targeted population of patients with septic shock due to intra...
Book Chapter
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 25
Published: 31 March 2009
10.1159/000209483
EISBN: 978-3-8055-9024-2
Book Chapter
Book Chapter
Series: Medicine and Sport Science
Volume: 52
Published: 05 June 2008
10.1159/000134302
EISBN: 978-3-8055-8490-6
... Chi on RA, we conducted a pilot randomized controlled trial. Twentypatients with functional class I or II RA were randomly assigned to Tai Chi or attention controlin twice-weekly sessions for 12 weeks. The American College of Rheumatology (ACR)20 response criterion, functional capacity, health-related...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102314
EISBN: 978-3-318-01467-9
... histologically diagnosed as IgAN at thispoint of declining renal function. Twelve patients were eligible for trial entry; reciprocalserum creatinine plot suggested end-stage renal failure within 5 years. All patients weretreated with continuous intravenous infusion of heparin for 8 weeks, followed by oral...
Book Chapter
Book Chapter
Series: Frontiers in Diabetes
Volume: 18
Published: 09 September 2005
10.1159/000088087
EISBN: 978-3-318-01241-5
... control, knowledge of diabetes, health behavior and quality of life in type 2diabetes. A clinical trial (ROMEO) was planned to evaluate the applicability and reproducibilityof Group Care in other centers and in a larger patient population. ROMEO is amulticenter, randomized, controlled clinical trial...
Book Chapter
Series: Contributions to Nephrology
Volume: 149
Published: 10 May 2005
10.1159/000085457
EISBN: 978-3-318-01222-4
... and morbidity in ultrapure bicarbonate dialysis (BD) with on-line predilutionhemofiltration (HF). Since comorbidity is one of the main factors limiting survival,the study was addressed to patients with a severe degree of comorbidity. The paper presentsthe preliminary results of the trial. Sixty-four patients...