... Abstract Improved maternal nutritional status is hypothesized to promote good pregnancy and infant health outcomes but trial evidence supporting the commencement of nutritional supplementation before conception is sparse. The NiPPeR ( Nutritional Intervention Preconception and During Pregnancy...

... Abstract In this essay, we propose an association between Franz Kafka's novel, The Trial , and phenomenological and neurobiological processes in schizophrenia. We begin by presenting a summary of the plot, pointing to some of its remarkable literary aspects. We next compare the mental...

... Abstract Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness. This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical...

... Abstract Physicians rely on safety and efficacy data from pivotal trials to guide treatment decisions and manage patients. Even with robust clinical trial data, there remain questions regarding rare safety events and generalizability. Registries complement clinical trials. By evaluating...

... Abstract Two critical questions one must answer as one applies the results of a clinical trial to clinical practice are: (1) Regardless of whether the trial result is likely to be replicated or reproduced in a second large-scale trial, are the results likely to be reproduced in one's practice...

... Abstract Background: According to the Directive 2001/20/EC of the European Union, a clinical trial is any investigation in human subjects intended to (1) discover or verify the clinical, pharmacological, and/or other pharmacodynamic effects of one or more investigational medicinal product(s...

... decline during antihypertensive and antiproteinuric therapy over an observation period of at least 6 months (1B) or in patients with severe, disabling, or life-threatening symptoms related to their NS (1C) [ 7 ]. Although a number of randomized, controlled trials of different immunosuppressive agents...

...-negative or mixed pathogens, and is likely associated with high endotoxin levels. Therefore, it represents a condition in which endotoxin-targeted therapy may be of particular benefit [ 3 ]. The EUPHAS study, a randomized controlled trial in a targeted population of patients with septic shock due to intra...

... Chi on RA, we conducted a pilot randomized controlled trial. Twentypatients with functional class I or II RA were randomly assigned to Tai Chi or attention controlin twice-weekly sessions for 12 weeks. The American College of Rheumatology (ACR)20 response criterion, functional capacity, health-related...

... histologically diagnosed as IgAN at thispoint of declining renal function. Twelve patients were eligible for trial entry; reciprocalserum creatinine plot suggested end-stage renal failure within 5 years. All patients weretreated with continuous intravenous infusion of heparin for 8 weeks, followed by oral...

... control, knowledge of diabetes, health behavior and quality of life in type 2diabetes. A clinical trial (ROMEO) was planned to evaluate the applicability and reproducibilityof Group Care in other centers and in a larger patient population. ROMEO is amulticenter, randomized, controlled clinical trial...