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treg

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Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 62
Published: 04 February 1988
10.1159/000415481
EISBN: 978-3-318-03326-7
Book Chapter
Book Chapter
Book Chapter
Series: Progress in Tumor Research
Volume: 1
Published: 30 November 1959
10.1159/000385942
EISBN: 978-3-318-04154-5
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 11
Published: 18 February 2010
10.1159/000289201
EISBN: 978-3-8055-9384-7
... (Tregs), which comprise ∼10% of peripheral CD4 cells, as pivotal regulators of immune responses has provided a new framework to define the cellular and molecular basis underlying the contrasting action of TNF. TNF by itself can overcome the profound anergic state of T cell receptor-stimulated Tregs...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154854
EISBN: 978-3-8055-8629-0
... rather than immunity. Functional analyses revealed recently that steady-state dendritic cells and alternatively activated macrophages, respectively, actively induce regulatory T cells (Tregs) in the periphery of the body. Thus, production of Tregs does not rely exclusively on thymic development. Vice...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000155000
EISBN: 978-3-8055-8629-0
... Abstract Allergen-specific immunotherapy (SIT) is the only treatment which leads to a lifelong tolerance against previously disease-causing allergens due to restoration of normal immunity against allergens. The description of T-regulatory (Treg) cells being involved in prevention...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154999
EISBN: 978-3-8055-8629-0
... Abstract Natural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
10.1159/000353557
EISBN: 978-3-318-02481-4
... Abstract Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by ‘low-degree' chronic inflammation and are associated with an increased risk...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154869
EISBN: 978-3-8055-8629-0
... Abstract Effector and regulatory T cells (Tregs) play a fundamental role in the airways in allergic asthma. Here, the role of T cells in the immunopathogenesis of human asthma as well as in animal models of allergic airway inflammation is reviewed. Recent data have shown that Th2 and Th17...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454703
EISBN: 978-3-318-06025-6
... cells (Tregs), whose normal function is to maintain immunological tolerance. Similar to other primary defects of the immune system, IPEX clinical manifestations occur during early infancy. Of these, type 1 diabetes mellitus (T1D) together with enteropathy and eczema are common signs of the typical forms...
Book Chapter
Series: Contributions to Nephrology
Volume: 146
Published: 28 October 2004
10.1159/000082072
EISBN: 978-3-318-01168-5
... Abstract It is now well recognized that regulatory T cells (Treg) play a central role in the controlof both reactivity to self-antigens and alloimmune response. Several subsets of Treg withdistinct phenotypes and mechanisms of action have now been identified. They constitute anetwork...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154846
EISBN: 978-3-8055-8629-0
... Abstract Foxp3-expressing regulatory T cells (Tregs) have an essential function of preventing autoimmune disease in man and mouse. Foxp3 binds to forkhead motifs of about 1,100 genes and the strength of binding increases upon PMA/ionomycin stimulation. In Foxp3-expressing T-cell hybridomas...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154855
EISBN: 978-3-8055-8629-0
... Abstract Interest in regulatory T cells (Treg) and their role in immune regulation has grown almost exponentially over the last 10 years, though the notion of a suppressive population of T cells has been in existence since the early 1970s. Recent reports have highlighted the potential role...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000155086
EISBN: 978-3-8055-8629-0
... of allergy. The balance between T-helper (Th)2 cells and T-regulatory (Treg) cells has a critical role in the generation of immune responses to environmental antigens. Allergic individuals display an aberrant activation and expansion of Th2 cells. It appears that aberrant activation of Th2 cells in allergy...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444973
EISBN: 978-3-318-05867-3
... mitigation of T-cell activation and induction of T-cell anergy and regulatory T cells (Tregs). Later, the molecules such as indoleamine dioxygenase, heme oxygenase, program death-1 receptor, and HLA-G were found to participate. Besides T cells, infused DCs also modulate B-cell functions and production...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346523
EISBN: 978-3-318-02348-0
... epithelial barrier, and immune system development. We have recently shown that a defined mixture of 46 strains of mouse-derived Clostridium species belonging to clusters XIVa and IV affects the development and function of colonic Foxp3+ CD4+ regulatory T (Treg) cells in mice. Clostridium -induced Treg...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154998
EISBN: 978-3-8055-8629-0
... (Tregs) that mediate directly the suppression of T cells that effect delayedtype hypersensitivity (DTH). Here we review investigations that demonstrate: (i) the injection of antigen into the anterior chamber (AC) attracts circulating monocytic cells to the iris/ciliary body that recirculate to the thymus...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000155088
EISBN: 978-3-8055-8629-0
... drives the investigation of antigen-based tolerance in rodent models and in patients. The identification of the key role T-regulatory cells (Tregs) play in avoidance of immunopathology focused on either self or environmental antigens has led to a need to determine whether established and novel tolerance...