Search Results for tolerance

..., such as combinations of growth restriction, antenatal blood flow concerns, intensive supportive needs (including inotropes), and large open patent ductus arteriosus, currently poorly represented in feeding trials. Infant tolerance monitoring includes clinical observations (stooling, abdominal size, vomiting...

.... Inducing donor-specific immune tolerance in VCA can conceivably be the solution to this dilemma. Creating chimerism by means of donor cell transfer and repopulation is proposed to be a powerful and efficient tool to promote donor-specific immune tolerance. In this chapter, we describe the theory...

.... Induction of donor-specific tolerance to eliminate the requirement of immunosuppression has thus become an ultimate goal that is actively pursued in the field of transplantation. Among the various strategies, great potential has been shown with cellular therapeutics in many animal studies. This chapter...

... Abstract Food allergy is an important and increasing public health problem worldwide, affecting predominantly infants and young children. There is an urgent need to develop effective treatment strategies to restore oral tolerance in food-allergic individuals. Among diverse research approaches...

... non-IgE-mediated food allergy is most commonly cell-mediated. These food allergies are thought to occur as a result of a breakdown in oral tolerance and, more specifically, from an aberrant regulatory T-cell response. Ongoing studies of experimental treatments for food allergy strive to induce oral...

... of muscular work. Fig. 1 Pulmonary oxygen uptake ( V · O 2 ) for a representative individual during severe-intensity cycle exercise continued until the limit of tolerance following nitrate (beetroot juice) and placebo supplementation. The dotted vertical line represents the abrupt imposition...

... Abstract In allergic diseases, immune responses are induced by normally well-tolerated allergens, which result in chronic inflammation characterized by antibody secretion and T cell activation. For almost 100 years, allergen-specific immunotherapy (allergen-SIT) has been the potentially...

... Abstract Penicillin resistance and tolerance has been an increasing threat to the treatment of pneumococcal pneumoniae. However, no penicillin tolerance-related genes have been claimed. Here we show that a major heat shock protein ClpL/HSP100 could modulate the expression of a cell wall...

... Abstract There is a vast scientific literature on the innate and adaptive immune responses that contribute to the development of tolerance with growing appreciation that innate and adaptive immunity do not function independently of each other. Innate immune pathways of current interest...

... limitations in older or multisensitized patients. Allergy research therefore aims at establishing new and more efficacious treatment strategies in prophylactic as well as therapeutic settings. Our research programs focus on the development of novel allergy vaccines based on the induction of mucosal tolerance...

... Abstract The development of oral tolerance occurs during critical early stages of immune development. Rising rates of food allergy and other immune-mediated food reactions are an indication that oral tolerance is highly susceptible to environmental change. There is growing evidence...

... (Tregs) to inhibit aspects of innate and adaptive antifungal immunity is required for protective tolerance to fungi. Indoleamine 2,3-dioxygenase (IDO) and tryptophan catabolites contribute to such a homeostatic condition by providing the host with immune defense mechanisms adequate for protection...