... Abstract In the sensory hair cells of the mammalian cochlea, the primary cilia in the planar cell polarity as well as the tight junctions in the epithelial cell polarity and the barrier are important to maintain normal hearing. Temperature-sensitive mouse cochlear precursor hair cells were used...

... Abstract Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e.g. the stratum corneum barrier, and are influenced by other skin barriers, e.g...

... Abstract Respiratory syncytial virus (RSV) primarily infects upper respiratory tract cells, mainly nasal epithelial cells. The tight junctions of nasal epithelial cells are thought to perform important innate immune function against foreign materials including respiratory viruses. We...

.... The epithelial barrier function is regulated in large part by the apical-most intercellular junction, referred to as the tight junction. Antigen-presenting cells, particularly dendritic cells (DCs), are known to play an important role in human nasal mucosa. Recently, the author and colleagues discovered a new...

... on the apical tight junctions. The tight junctions are membrane fusion areas between adjacent cells that serve as a diffusion barrier for paracellular transport and as a ‘molecular fence’, restricting the free movement of transmembrane proteins, and thus maintaining cell polarity and the asymmetric distribution...

... Abstract Optimum eye care of patients with diabetes requires, first of all, tight glycemic and blood pressure control as well as correction of anemia and hyperlipidemia. There is evidence that tight control of glycemia reduces the risk of development and progression of diabetic retinopathy...

... dentine. This means removal to hard dentine around the periphery, to firm dentine centrally for optimising restoration longevity and allowing a tight cavity seal. For deep lesions in teeth with vital pulps (without irreversible pulpitis), maintaining pulp vitality is critical. Dental practitioners should...

... Abstract The epithelium of upper respiratory tissues such as the human nasal mucosa forms a continuous barrier via tight junctions (TJs). The development of a drug delivery system for use across the nasal mucosa is being reconsidered. In intranasal administration across the nasal mucosa...

.... Strategies that have been suggested for preventing reperfusion-related ICH in high-risk patients include intensive blood pressure control, tight glycemic control, and the avoidance of early aggressive antithrombotic therapy. If sICH, and especially massive parenchymal hematoma, does occur, hematoma expansion...

...References References 1. Aijaz S, Balda MS, Matter K: Tight junctions: molecular architecture and function. Int Rev Cytol 2006;248:261-298. 2. DiTommaso T, Cottle DL, Pearson HB, Schluter H, Kaur P, Humbert PO, Smyth IM: Keratin 76 is required for tight junction function and maintenance...

... are tight junctions, protein structures located in the paracellular channels between epithelial cells of the intestinal wall. The integrity of tight junctions depends on sophisticated interactions between the gut residents and their expressed substances, the intestinal epithelial cell metabolism...

... Abstract Bunionette-type deformity consists of the painful prominence of the head of the 5th metatarsal. Although its exact etiology is not completely known, tight shoes and friction generated between the bony prominence, soft tissue, and associated constrictive footwear can result in keratosis...

... Abstract Blood-retinal barrier breakdown with macular edema is caused by many diseases, which modulate – via different growth factors – the integrity of the tight junctions. Starling’s law predicts furthermore that macular edema will develop if the hydrostatic pressure gradient between...

... penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis. J Histochem Cytochem 2005;53:611-619. 3. Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii...

... Abstract Stress has been defined as an acute threat to the homeostasis of the organism. Themucosal lining of the gastrointestinal tract, a single layer of epithelial cells heldtogether by tight junctions, provides a barrier between the external environment andthe body’s internal milieu. Any...

... Abstract Facial rejuvenation should focus on reversing the aging process by addressing skin texture, tone, and tightness. Dermatologists accomplish this by addressing skin laxity, deep folds, and dyschromia that combine to create an aged or dulled appearance. Cosmeceuticals act as adjuvants...

... proteins. The two main types of junctional complex present in salivary gland luminal epithelium are (1) tight junctions and (2) adherens junctions. Here we will describe these types of cell-cell junction in turn, describing their distribution in the developing salivary glands, and discussing...

... of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn 2008;237:3128-3141 15. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S: Occludin - a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993;123:1777-1788 16. Furuse M, Itoh M...

...References References 1. Shen L, Weber CR, Raleigh DR, et al: Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol 2011;73:283-309. 2. Garcia MA, Yang N, Quinton PM: Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent...