... Abstract Safety and efficacy of intravenous (IVT) and intra-arterial thrombolysis (LIT) in patients with acute stroke due to spontaneous cervical artery dissection were not assessed in any controlled randomized trial. Data on IVT are derived from 4 studies with a total of 50 patients aged 48...

...References References 1. Sobbe A, Stumpff U, Trübestein G, et al: [Thrombolysis by ultrasound (author's transl)]. Klin Wochenschr 1974;52:1117-1121. 2. Harpaz D, Chen X, Francis CW, et al: Ultrasound accelerates urokinase-induced thrombolysis and reperfusion. Am Heart J 1994;127:1211-1219...

... with ischemic stroke. Mechanisms of Ultrasound Thrombolysis Despite numerous studies documenting a thrombolytic effect of US, the mechanisms of this effect remain poorly understood. Inertial cavitation (i.e. the formation and violent collapse of gas-filled bubbles in a fluid exposed to US) gives rise...

...References References 1. Emberson J, Lees KR, Lyden P, et al: Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014;384:1929-1935...

... Abstract Heparin is the standard of care in cerebral venous thrombosis. Local thrombolysis isbelieved to better restore venous blood flow than heparin. Thrombolysis is also used whenthe patient’s condition worsens despite heparin and symptomatic treatment. The most frequentlydescribed cause...

... Abstract The enhancement of thrombolysis by ultrasound energy (sonothrombolysis) is anemerging field of interest in the treatment of acute ischemic stroke. Recent in vitro and clinicalstudies have investigated the effects of using transcranially applied ‘diagnostic’ ultrasoundfor this purpose...

... Abstract The efficacy of intravenous thrombolysis (IVT) for acute ischemic stroke patients has been well established worldwide, with endovascular therapy performed in patients who have failed or are ineligible for IVT and who have major vessel occlusion. The most feared complication of acute...

... weightadjustedsubcutaneous low molecular weight heparin, the use of thrombolysis, and symptomatictherapy including control of seizures and elevated intracranial pressure. We reviewed thestrength of evidence reported in the literature to support these interventions and provide treatmentrecommendations based on the best...

... Investigators: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Me 2008;359:1317-1329 17. Furlan A, Higashida R, Wechsler L, et al: Intra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: a randomized controlled trial. JAM 1999;282:2003-2011 18. Donnan...

... and opens the window of treatment up to at least 6 h but consequencesinvasive intra-arterial angiography in a high number of patients, of whom a significant numberdo not finally receive thrombolysis. The combination of ultrasound with thrombolyticagents may enhance the potential benefit by means of enzyme...

... fibroblastic and/or smooth muscle cell reaction) were identified. Microthrombi in the former three types showed various degrees of thrombolysis. Failure of thrombolysis seemed to lead the organization of microthrombi. These morphological findings were considered to indicate the course of DIC and the degree...

... it needs longer execution time and patient collaboration. Digital subtraction angiography represents the gold standard and allows both diagnosis and therapeutical intervention. Treatment The safety and efficacy of intravenous thrombolysis given 4.5 h from the onset of symptoms in acute ischemic...

..., disorders of reading may be seen after unilateral left infarction and disorientation for place and visual neglect after right lesion. After bilateral PCA infarcts, amnesia, cortical blindness (the patient cannot see but pretend he can) may occur. Acute thrombolysis is as useful after PCA infarctions...

... the results of future prospective randomised controlled trials a decade or more before the trials are completed and published. Countless such examples exist in the literature, as is the case for thrombolysis in patients with myocardial infarction in the last millennium: meta-analysis determined the efficacy...

... syndromes. (eds) Ginsberg MD, Bogousslavsky J: Cerebrovascular Disease: Pathophysiology, Diagnosis and Managemen Malden, Blackwell Science, 1997;1028-1045 3. Breuer L, Huttner HB, Jentsch K, Blinzler C, Winder K, Engelhorn T, et al: Intravenous thrombolysis in posterior cerebral artery infarctions...

...-thrombolysis of intracerebral hemorrhage and its impact on perihematoma brain edema. Neurocrit Care 2008;8:322-329. 17. Liu W, Ma L, Shen F, et al: Drilling skull plus injection of urokinase in the treatment of epidural haematoma: a preliminary study. Brain Inj 2008;22:199-204. 18. Liu C, Ling F...

.... Sabatine MS, Cannon CP, Gibson CM, López-Sendón JL, Montalescot G, Theroux P, Lewis BS, Murphy SA, McCabe CH, Braunwald E: Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators: Effect of clopidogrel pretreatment before percutaneous coronary...

..., emboli monitoring, vasomotor reactivity testing, brain death as well as monitoring during carotid endarterectomy, coronary artery bypass graft operations and thrombolysis for acute ischemic stroke [ 11 ]. For patients with intracranial atherosclerotic disease, TCD serves as an initial and reliable...