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Book Chapter
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 122
Published: 03 September 2021
10.1159/000514737
EISBN: 978-3-318-06647-0
... as well as therapeutic purposes. The history of these products with their potential benefits for humans dates back thousands of years, well before our current understanding of their connection to microbes [ 2 ]. The relationship of microbes found in infant foods was first published by Theodor...
Book
Book Chapter
Book
Book Cover Image
Series: Fast Facts Online
Published: 14 April 2020
10.1159/isbn.978-3-318-06667-8
EISBN: 978-3-318-06667-8
Book
Book Chapter
Series: Progress in Neurological Surgery
Volume: 32
Published: 23 July 2018
10.1159/000469689
EISBN: 978-3-318-06063-8
... certain therapeutic potential for possible use in neuro-oncology and neurosurgery. Introduction Since the first descriptions of extracellular vesicles (EV) emerged over three decades ago [ 1 , 2 ], much interest has arisen regarding these small secreted organelles and their role in human disease...
Book Chapter
Series: Contributions to Nephrology
Volume: 195
Published: 22 May 2018
10.1159/000486930
EISBN: 978-3-318-06350-9
..., has attained more attention lately, since treatment with rituximab, a monoclonal antibody directed against CD20 bearing cells, has shown good therapeutic responses in the treatment of MCNS. Mechanism of Rituximab Action CD20 is a hydrophobic transmembrane protein, with a molecular weight...
Book Chapter
Series: Medicine and Sport Science
Volume: 62
Published: 19 June 2017
10.1159/000460700
EISBN: 978-3-318-06044-7
..., it was recognized that athletes experiencing illness or injury might legitimately require the use of “prohibited” medications or procedures, and the concept of the “therapeutic use exemption” (TUE) was introduced. The mechanisms of the TUE process are carefully defined and described in a specific WADA...
Book Chapter
Series: Contributions to Nephrology
Volume: 189
Published: 22 December 2016
10.1159/000450776
EISBN: 978-3-318-05929-8
... with an arrested cell cycle and decreased expression of Klotho protein. Because cell cycle arrest has a protective effect on organs in the acute phase, the proposed therapeutic target against the aging process is to maintain expression of Klotho protein. In addition, it is recognized that TGF-β 1 plays a central...
Book Chapter
Series: ESASO Course Series
Volume: 7
Published: 06 April 2016
10.1159/000442229
EISBN: 978-3-318-05619-8
... on its long-term safety and efficacy. Conclusion Therapeutic options for intraocular retinoblastoma continue to evolve. The popularity of chemotherapy during the past decade has spared many young children the side effects of external beam radiation. Even with the emergence of local methods...
Book Chapter
Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/000439372
EISBN: 978-3-318-05639-6
... Abstract This chapter deals with novel therapeutic approaches, predominantly for type 2 diabetes. Incretin-based therapies utilize the effects of glucagon-like peptide-1 (GLP-1), which stimulates insulin and inhibits glucagon secretion in a glucose-dependent manner. Incretin-based therapies...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439337
EISBN: 978-3-318-05637-2
... therapeutic options in pediatric and adult hormone-dependent diseases. The development of synthetic molecules that modulate reproductive hormones has had a major impact on human lifestyle and health. The contraceptive pill for women is considered to be amongst the most important contributions...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439340
EISBN: 978-3-318-05637-2
... in the accumulation of very-long-chain fatty acids (VLCFA) in organs and plasma. Recent findings on pathomechanisms of the peroxisomal neurometabolic disease X-ALD have provided important clues on therapeutic targets. Here we describe the impact of chronic redox imbalance caused by the excess VLCFA on mitochondrial...
Book Chapter
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000431200
EISBN: 978-3-318-05565-8
... in a nonhuman primate [ 16 ]. Neovascular Age-Related Macular Degeneration In phase III trials in patients with neovascular AMD, ranibizumab was the first therapeutic agent to demonstrate a mean improvement in visual acuity (VA) and patient-reported outcomes. Data from two pivotal, multicenter...
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000438954
EISBN: 978-3-318-05565-8
... A available to the retina for inclusion in photoreactive molecules [ 23 ] while Ret-NH 2 directly antagonized RPE65 [ 30 ]. Preclinical Trials In two mouse models for retinal degeneration, retinylamine showed the greatest therapeutic potential as it was the only compound that significantly decreased...
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000438953
EISBN: 978-3-318-05565-8
... therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade...
Book
Book Cover Image
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/isbn.978-3-318-05497-2
EISBN: 978-3-318-05497-2
Book
Book Cover Image
Series: Nestlé Nutrition Institute Workshop Series
Volume: 79
Published: 10 September 2014
10.1159/isbn.978-3-318-02670-2
EISBN: 978-3-318-02670-2