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Book Chapter
Book Chapter
Series: Frontiers of Oral Biology
Volume: 12
Published: 04 February 2008
10.1159/000115038
EISBN: 978-3-8055-8152-3
... expression of various transforming growthfactor-Β (Tgf-Β) isoforms plays a crucial role in regulating suture patency once the sutureshave formed. It has also been shown that differential expression of Tgf-Β isoforms may alsoplay a role in craniosynostosis by altering proliferation, differentiation...
Book Chapter
Series: Contributions to Nephrology
Volume: 139
Published: 03 June 2003
10.1159/000071736
EISBN: 978-3-318-00964-4
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 5
Published: 19 December 2001
10.1159/000060548
EISBN: 978-3-318-00773-2
Book Chapter
Series: Contributions to Nephrology
Volume: 135
Published: 04 October 2001
10.1159/000060162
EISBN: 978-3-318-00748-0
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Book Chapter
Series: Frontiers of Hormone Research
Volume: 20
Published: 12 April 1996
10.1159/000425147
EISBN: 978-3-318-03666-4
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Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000324949
EISBN: 978-3-8055-9743-2
... Abstract Diabetic nephropathy (DN) is a major diabetic complication. Transforming growth factor-β(TGF-β) is a key mediator in the development of diabetic complications. It is well known that TGF-β exerts its biological effects by activating downstream mediators, called Smad2and Smad3, which...
Book Chapter
Series: Biovalley Monographs
Volume: 3
Published: 28 August 2012
10.1159/000339188
EISBN: 978-3-8055-9066-2
... Abstract Transforming growth factor-beta (TGF-β) comprises multifunctional extracellular signaling molecules acting in the nervous system from early development into adulthood. The TGF-β superfamily constitutes a group of 33 members. Many of these execute important functions during early...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 77
Published: 30 September 2013
10.1159/000351390
EISBN: 978-3-318-02447-0
... by the microenvironment (DC conditioning) will be discussed in this review. High concentrations of retinoic acid or vitamin D metabolites, thymic stromal lymphopoietin and/or transforming growth factor-β (TGF-β) activate signaling programs in DC that yield in priming of regulatory and anti-inflammatory T cell responses...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320827
EISBN: 978-3-8055-9567-4
...The targets Transforming growth factor-β (TGF-β) is a pleiotropic cytokine, ubiquitously expressed by all cells and tissues in the body. TGF-β is syndiesized as an inactive molecule, latent TGF-β, which needs to be activated to exert its biological effect. Active TGF-β is involved...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320828
EISBN: 978-3-8055-9567-4
...The target The transforming growth factor-ß (TGF-ß) receptor complex is a tetramer consisting of two dimers: two TGF-ß type II and two type I receptors (TGF-ßRII and TGF-ßRI) ( Fig. 1 ). TGF-ßRII and TGF-ßRI (also known as activin receptor like kinase 5 or ALK5) are transmembrane serine...
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000325647
EISBN: 978-3-8055-9743-2
...) reveal colocalization of AGE and ICAM-1 in proximal tubules. The biologically active carbonyl intermediates methylglyoxal-BSA-AGE and AGE-BSA upregulate tubular expression of CTGF, TGF-β, and VEGF, whereas carboxymethyllysine-BSA stimulates tubular expression of IL-6, CCL-2, CTGF, TGF-β, and VEGF via...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500387
EISBN: 978-3-318-06540-4
...-cell activation through the expression of HLA class II antigens and adhesion molecules [ 14 - 16 ]. In response to various stimuli, they can also produce a variety of chemokines, cytokines, and growth factors, such as transforming growth factor-β1 (TGF-β1), epidermal growth factor, tumor necrosis...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313743
EISBN: 978-3-8055-9473-8
... of soluble mediators including transforming growth factor-Β (TGF-Β) initiate a variety of pathophysiological processes at the beginning of kidney injury. TGF-Β also plays a fundamental role in cell proliferation and interstitial fibrosis in later phases. The renin-angiotensin-aldosterone system, especially...