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superantigen

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Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100858
EISBN: 978-3-318-01451-8
... is synthesized in low concentrations by the human liver, and is increased inbiological fluids of patients with viral hepatitis. This protein binds with high affinity to thevariable domain of the heavy chains of all human immunoglobulins. Thus, it is an endogenousimmunoglobulin superantigen because it binds...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100862
EISBN: 978-3-318-01451-8
... Abstract Bacterial and viral superantigens (SAgs) can induce the activation of a large fraction ofthe T cells in an individual. The activated T cells divide and produce a strong cytokineresponse. Subsequently, the majority of the expanded T cells are deleted and the remainingSAg-reactive cells...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100895
EISBN: 978-3-318-01451-8
... to be associatedwith atopic dermatitis. Here we summarize recent findings suggesting a role forstaphylococcal superantigens in the production of chemokines during the development ofatopic skin inflammation. ...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/000319136
EISBN: 978-3-318-01608-6
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/000421659
EISBN: 978-3-318-01608-6
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100851
EISBN: 978-3-318-01451-8
... Abstract Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. They activatethe immune system by binding to the major histocompatibility complex (MHC) class IIand T cell receptor molecules. One of the major producers of SAgs is Streptococcus pyogenes,or group...
Book
Book Cover Image
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/isbn.978-3-318-01451-8
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/000319131
EISBN: 978-3-318-01608-6
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/000421656
EISBN: 978-3-318-01608-6
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100859
EISBN: 978-3-318-01451-8
... Abstract Yersinia pseudotuberculosis, a gastro-intestinal bacterium, produces three closelyrelated T cell superantigens, YPMa, YPMb and YPMc, which have no significant sequencesimilarity to other proteins, let alone other bacterial superantigens. Y. pseudotuberculosisderivedmitogen (YPM) has...
Book
Book Cover Image
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/isbn.978-3-318-01608-6
EISBN: 978-3-318-01608-6
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100897
EISBN: 978-3-318-01451-8
... Abstract Gram-positive Staphylococcus aureus germs constitutively have the possibility torelease classical and egc-locus-derived enterotoxins which show superantigen activity, andeffectively modify the functions of T and B cells, eosinophils, and other inflammatory andstructural cells...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 55
Published: 25 August 1992
10.1159/000421655
EISBN: 978-3-318-01608-6
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100894
EISBN: 978-3-318-01451-8
... Abstract Bacterial superantigens (SAgs) constitute a large family of bacterial toxins that sharethe capacity to induce massive activation of the human immune system. Such a feature isbased on the ability of these toxins to activate T cells that express Β-chains of the T cell antigenreceptor...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 96
Published: 16 March 2012
10.1159/000331887
EISBN: 978-3-8055-9895-8
... flora [ 1 ]. S. aureus skin colonization is found in over 90% of AD patients (in contrast with only 5% of normal individuals) and occurs on both lesional and, to a lesser proportion, nonlesional AD skin [ 1 , 2 ]. The role of staphylococcal enterotoxins acting as superantigens in AD has recently...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100860
EISBN: 978-3-318-01451-8
... Abstract Some infectious agents produce molecules capable of interacting specifically with theimmunoglobulin variable regions, independently of the conventional binding site. They arereferred to as B cell superantigens, and include protein A of Staphylococcus aureus, proteinL...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100861
EISBN: 978-3-318-01451-8
.... But superantigens produced by S. aureus in these locations are of particular interestbecause they are strongly implicated in the pathogenesis of allergic disorders and airway disease.They appear to act locally in these conditions by stimulating polyclonal T cell and B cellproliferation and driving somatic...
Book Chapter