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superallergen

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Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100858
EISBN: 978-3-318-01451-8
... to human immunoglobulin of the VH3family. This protein also acts as a superallergen because it activates human basophils andmast cells through the high-affinity interaction with IgE VH3+. The mechanism of activationof immune cells by protein Fv represents a new pathogenetic cascade consisting...
Book
Book Cover Image
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/isbn.978-3-318-01451-8
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100896
EISBN: 978-3-318-01451-8
..., an endogenous protein synthesized in the human liver and increased during viralhepatitis, act as a superallergen by binding to IgE of the VH3 family and activating humanbasophils and mast cells. Similarly, envelope gp120 of HIV-1 and protein A ofStaphylococcus aureus are viral and bacterial superallergens...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100861
EISBN: 978-3-318-01451-8
... hypermutation, class switching to immunoglobulin (Ig) E andthe production of allergen-specific IgE in mucosal B cells. IgE antibodies directed against thesuperantigens (‘superallergens’) themselves engender chronic inflammation and the persistentsensitization to conventional allergens of mast cells and antigen...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100852
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100851
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100856
EISBN: 978-3-318-01451-8
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100859
EISBN: 978-3-318-01451-8
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100862
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100894
EISBN: 978-3-318-01451-8
Book Chapter
Book Chapter
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100899
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 93
Published: 20 March 2007
10.1159/000100900
EISBN: 978-3-318-01451-8
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
EISBN: 978-3-318-02195-0
... disease. Adv Immunol 1993;54:99. 148. Marone G, Rossi FW, Detoraki A, Granata F, Genovese A, Spadaro G: Role of superallergens in allergic disorders. Chem Immunol Allergy 2007;93:195. 149. Marrack P, Kappler J: The staphylococcal enterotoxins and their relatives. Science 1990;248:705. 150...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358734
EISBN: 978-3-318-02195-0
... demonstrate that endogenous, viral and bacterial products can activate human basophils to release pro-inflammatory mediators and cytokines (IL-4 and IL-13) acting as immunoglobulin superantigens. In this context, the definition of immunoglobulin superantigens has been changed to ‘superallergens' [ 148...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441589
EISBN: 978-3-318-05586-3
... and acrylates, and has occurred simultaneously with severe ICD. It has been proposed that these be termed ‘superallergens' [ 67 ]. The Effect of Multiple Irritants In real life, just as multiple factors contribute to OCD, there is exposure to multiple irritants, and their impact and potential...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
EISBN: 978-3-318-02481-4
... superallergen protein Fv induces IL-4 secretion from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE. J Immunol 1998;161:5647-5655. 55. Genovese A, Borgia G, Bjorck L, Petraroli A, de Paulis A, Piazza M, Marone G: Immunoglobulin superantigen protein L induces IL-4 and IL-13...