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Book Chapter
Series: Contributions to Oncology
Volume: 35
Published: 09 August 1990
10.1159/000418862
EISBN: 978-3-318-03418-9
... Abstract SummaryThe combination of carboplatin, ifosfamide and etoposide shows a promising 52% response rate in 29 evaluable patients with non-small cell lung cancer. The dose-limiting factor was the hematological toxicity, including one septic/toxic death. ...
Book Chapter
Series: Contributions to Oncology
Volume: 6
Published: 08 July 1981
10.1159/000428662
EISBN: 978-3-318-03389-2
... Abstract SummaryThe results of chemotherapy with DDP, ADM, CCNU, CYT and VCR in inoperable non-small bronchogenic cancer are briefly detailed. Nearly 40 % remissions could be obtained. ...
Book Chapter
Published: 08 January 1970
10.1159/000388787
EISBN: 978-3-318-04672-4
... Abstract SummaryThe method for disaccharidase activity assay in peroral biopsies of the human small-intestinal mucosa is described in detail. The specificity of the enzymes and the clinical conditions affecting the intestinal disaccharidase activity are discussed. ...
Book Chapter
Published: 09 July 1969
10.1159/000388727
EISBN: 978-3-318-04662-5
... Abstract SummaryThe author considers it is safe to observe gastric polyps by gastroscopy at 6 months, later in yearly intervals. It is his policy not to operate unless the polyp changes rapidly in size and characteristics.Various gastric lesions are shown and discussed. ...
Book Chapter
Published: 08 January 1970
10.1159/000388786
EISBN: 978-3-318-04672-4
... Abstract SummaryThe enzymology of human renal tissue is at present a large field of investigation likely to provide in the future important information for clinical diagnosis and prognosis. It should be performed under quantitative aspects and in kidney biopsy material together with the use...
Book Chapter
Series: Contributions to Oncology
Volume: 26
Published: 24 November 1987
10.1159/000429562
EISBN: 978-3-318-03409-7
... Abstract SummaryThe stepwise development of ifosfamide-based combination regimens for lymphoma at the M. D. Anderson Hospital is summarized, starting with the single-agent phase-II study to the more recent MIME combination. A critical review of the ifosfamide papers presented at the ifosfamide...
Book Chapter
Series: Contributions to Oncology
Volume: 6
Published: 08 July 1981
10.1159/000428611
EISBN: 978-3-318-03389-2
... Abstract SummaryThe Vinca alkaloids, vinblastine, vincristine and vindesine, inhibit the invasion of mouse fibrosarcoma cells into chick cardiac muscle in vitro. This anti-invasive effect is ascribed to interference of these drugs with the assembly of the cytoplasmic microtubule complex...
Book Chapter
... Abstract SummaryThe mechanism of the pathogenesis of EAE now can be discussed more rigorously based on the genetically-restricted T cell subset-macrophage interacting system. Some representative drugs or compounds useful for the therapy of acute EAE are briefly reviewed. Two new promising...
Book Chapter
Series: Contributions to Oncology
Volume: 6
Published: 08 July 1981
10.1159/000428644
EISBN: 978-3-318-03389-2
... Abstract SummaryThe combination of vindesine and prednisone was administered to twenty-four patients with advanced multiple myeloma, resistant to alkylating agents. Vindesine was given at a dosage of 2 mg/m2 intravenously in two courses of weekly injections combined with oral prednisone. Twenty...
Book Chapter
Series: Contributions to Oncology
Volume: 26
Published: 24 November 1987
10.1159/000429528
EISBN: 978-3-318-03409-7
... Abstract SummaryThe combined treatment of ifosfamide (IFO) with mesna in the murine tumor models P388 leukemia, Lewis lung carcinoma, and a newly developed reticulum cell sarcoma had nearly the same effectiveness as the cytostatic alone. Mesna was administered in 100% or 50% of the IFO dose...
Book Chapter
Series: Current Problems in Dermatology
Volume: 11
Published: 02 November 1983
10.1159/000408671
EISBN: 978-3-318-03448-6
... Abstract SummaryThe metabolism of both free nucleosides and bases in hyperkeratosis induced by topical application of n-hexadecane on the epidermis of guinea pig was discussed, based on the technique of high-pressure liquid chromatography. The level of nucleosides and bases decreased...
Book Chapter
... Abstract SummaryThe late results of pulmonary resection for patients affected of ‘bronchiectatic disease’ (whose symptoms had started in early childhood) seem to be better when the resection takes place at a higher age.It appears that the bronchial susceptibility to bacterial or viral...
Book Chapter
Published: 08 January 1970
10.1159/000388789
EISBN: 978-3-318-04672-4
... Abstract SummaryThe data on bone and cartilage enzymology available in the literature and gained by our own experiments were reviewed and discussed in respect to their metabolic significance in bone and cartilage cell metabolism. Enzyme distribution patterns of main metabolic pathway enzymes...
Book Chapter
Series: Contributions to Oncology
Volume: 6
Published: 08 July 1981
10.1159/000428626
EISBN: 978-3-318-03389-2
... Abstract SummaryThe vindesine-prednisone combination was studied as an induction protocol in various hematological malignancies. A total of 62 patients participated in this protocol; 58 treatments were evaluable for therapeutic response. As regards therapeutic activity, this regimen appeared...
Book Chapter
Series: Contributions to Oncology
Volume: 14
Published: 24 February 1983
10.1159/000407953
EISBN: 978-3-318-03397-7
... Abstract SummaryThe results of clinical application of Ftorafur (FT) in gastrointestinal cancers are reviewed, and its antitumor activity and toxicity is compared to 5-FU.Our own as well as data from literature suggest similar antitumor activity of both FT and 5-FU when used in adequate doses...
Book Chapter
Series: Contributions to Oncology
Volume: 6
Published: 08 July 1981
10.1159/000428661
EISBN: 978-3-318-03389-2
... Abstract SummaryThe Takita concept was used postoperatively to treat 54 patients with non-small cell carcinoma.The effectiveness of Vincristine (group 1) and Vindesine (group 2) has been proven in combined therapy. There was no pretherapeutic selection according to limited, extensive...
Book Chapter
Series: Contributions to Oncology
Volume: 14
Published: 24 February 1983
10.1159/000407959
EISBN: 978-3-318-03397-7
... Abstract SummaryThe usual method of administration of tegafur in the USA was by a 1-2-h infusion of 2-2.25 g/m2/day x 5 days. This regimen produced excessive nausea and vomiting and limited results. However, when therapy was switched to the multiple daily dose (M.D.D.) method of administration...
Book Chapter
... Abstract SummaryThe diagnostic criteria for status asthmaticus are outlined as well as the basic pathophysiology with bronchial obstruction as the main feature, the net effect of which is impairment of ventilatory capacity, uneven ventilation, hyperinflation and arterial hypoxia.The effect...
Book Chapter
Published: 05 August 1985
10.1159/000411357
EISBN: 978-3-318-04935-0
... Abstract SummaryThe efficacy of treatments compared in a clinical trial should be evaluated on the basis of carefully defined criteria which are accurate and chosen to suit the aim of the trial. It is not always desirable to use “objective” criteria, which are always relative and even...
Book Chapter
Series: Current Problems in Dermatology
Volume: 11
Published: 02 November 1983
10.1159/000408677
EISBN: 978-3-318-03448-6
... Abstract SummaryThe cytoplasmic fine structures of both normal human cultured keratinocytes (NHK) and squamous cell carcinoma cells (HSC) were examined by electron microscopy using the whole-cell preparation method and stereo-viewing techniques.The presence of cytoplasmic fine network (CFN...