... and inhibitory signals that help regulate immune responses. Pharmacological inhibition of key immune checkpoints has proven to be one of the most successful strategies so far; inhibitory receptors like cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and PD-1 have been pioneered recently in the stage IV...

... reasons. The election culminated in the appointment of Fulgence Raymond as Charcot’s successor. Although such an impossible succession was beyond Raymond, his work in neurology, which is often unrecognised, made him one of the most important neurologists of the early 20th century. In 1881...