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Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489530
EISBN: 978-3-318-06385-1
... of the lipid lamellae in the intercellular space of the stratum corneum (SC) and by quantitatively characterizing the composition of key SC lipids. Recently, the combination of a non-invasive lipid barrier visualization (Lipbarvis®) technique (SC sampling and morphometric analysis) and SC lipid composition...
Book Chapter
Series: Current Problems in Dermatology
Volume: 49
Published: 12 February 2016
10.1159/000441540
EISBN: 978-3-318-05586-3
... Abstract Human skin acts as a primary barrier between the body and its environment. Crucial for this skin barrier function is the lipid matrix in the outermost layer of the skin, the stratum corneum (SC). Two of its functions are (1) to prevent excessive water loss through the epidermis and (2...
Book Chapter
Series: Current Problems in Dermatology
Volume: 29
Published: 12 December 2000
10.1159/000060651
EISBN: 978-3-318-00629-2
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Series: Current Problems in Dermatology
Volume: 11
Published: 02 November 1983
10.1159/000408684
EISBN: 978-3-318-03448-6
... Abstract SummaryThe origin of free amino acids and/or their metabolites of the stratum corneum was investigated by pulse-chase experiments using hairless mice.Two, 24, 48, and 72 hrs after the animals were pulse-chased with 3H- histidine or 3H-arginine, radioactivity was determined...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396298
EISBN: 978-3-318-03447-9
... Abstract The stratum corneum basic protein (SCBP) aggregates specifically with keratin filaments, forming macrofibrils in which the filaments are highly aligned. The appearance of the macrofibrils formed in vitro is similar to the keratin pattern in the intact stratum corneum, suggesting...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396302
EISBN: 978-3-318-03447-9
... Abstract Fibrous proteins of human stratum corneum were isolated with urea-Tris buffer (pH 9.0) with and without 2-mercaptoethanol (2ME). Comparative studies were made of the biochemical and morphological properties of purified samples obtained with and without 2ME. The final yield of fibrous...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
EISBN: 978-3-318-06385-1
...References References 1. Neubert R, Rettig W, Wartewig S, Wegener M, Wienhold A: Structure of stratum corneum lipids characterized by FT-raman spectroscopy and DSC. II. Mixtures of ceramides and saturated fatty acids. Chem Phys Lipids 1997;89:3-14. 2. Madison KC, Swartzendruber DC, Wertz...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
EISBN: 978-3-318-06385-1
... Dermatol 2000;17:45-51. 7. Schmid-Wendtner MH, Korting HC: The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol 2006;19:296-302. 8. Fluhr JW, Elias PM: Stratum corneum pH: formation and function of the “Acid Mantle”. Exogenous Dermatol 2002:163-175. 9. Chiou...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489521
EISBN: 978-3-318-06385-1
... is organized in the form of a gradient in the epidermis with low concentrations in the stratum basale and peak concentrations in the stratum granulosum . During the aging process, this epidermal gradient collapses. In this chapter, we describe how a drop of calcium in the stratum granulosum affects...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489519
EISBN: 978-3-318-06385-1
... Abstract The pH value is identified as an essential determinant for the lipid synthesis in the stratum corneum (SC). The activity of the enzymes that catalyse the transformation of lipid precursors into ceramides, free fatty acids or cholesterol highly depends on pH value. Additionally...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
EISBN: 978-3-318-06385-1
...References References 1. Fluhr J, Elias P: Stratum corneum pH: formation and function of the “acid mantle”. Exogenous Dermatol 2002;1:163-175. 2. Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM: Generation of free fatty acids from phospholipids regulates stratum corneum...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
10.1159/000489515
EISBN: 978-3-318-06385-1
... consequences. The formation of acid mantel is important for the integrity and cohesion of the stratum corneum, a key component of an intact epidermal barrier, as well as for multiple defensive functions of the skin. In this chapter, we review the mechanisms in pH development after birth. Furthermore, we focus...
Book Chapter
Series: Current Problems in Dermatology
Volume: 54
Published: 21 August 2018
EISBN: 978-3-318-06385-1
...References References 1. Behne MJ, Barry NP, Hanson KM, et al: Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J Invest Dermatol 2003;120:998-1006. 2. Ohman H, Vahlquist A: In vivo studies concerning...