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Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000403593
EISBN: 978-3-318-02773-0
... tumors (NETs). In addition, the expression of these GPCRs form the basis for treatment with receptor agonists and they can be used as targets for the diagnosis and treatment with radiolabeled receptor agonists. Without any doubt, somatostatin receptors (SSTR) have formed a cornerstone target...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 35
Published: 21 June 2006
10.1159/000094315
EISBN: 978-3-318-01379-5
... Abstract About a third of acromegalic patients are resistant to the currently commercially availablesomatostatin analogs (SA) octreotide and lanreotide. Such resistance is related to an overallreduction of somatostatin receptor (SSTR) density or to a differentiated expression of SSTRsubtypes...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000382135
EISBN: 978-3-318-02773-0
... in use, with the exception of somatostatin receptor (SSTR) 2 expression for predicting the amenability of a tumor to in vivo SSTR targeting for imaging or therapy. Classification of Neuroendocrine Neoplasms in the Gastroenteropancreatic System The histological diagnosis of neuroendocrine...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000382059
EISBN: 978-3-318-02773-0
... of imaging and/or subsequent therapy. Somatostatin Receptor-Based Imaging One of the characteristics of NETs is that they may express somatostatin receptors (SSTRs) on the cell surface. This receptor can be used to image tumors by using radiolabeled somatostatin analogs. In vivo visualization...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318508
EISBN: 978-3-8055-9445-5
...% of significant tumor shrinkage, respectively. The response to treatment is related to the expression of SSTR subtypes, so the best responders to SA are acromegalic patients whose tumors express mainly SSTR2, whereas adenomas of acromegalics partially or completely resistant to SA mainly express other SSTR...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318506
EISBN: 978-3-8055-9445-5
... belong to the seven-transmembrane-domain G-protein-coupled receptors [ 11 ]. Octreotide and lanreotide, primarily bind to SSTR2 and with less affinity to SSTR5. Hence, there was intensive search for metabolically stable analogs mimicking the ability of the native somatostatin-14 to bind several SSTRs...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 45
Published: 21 March 2016
10.1159/000442331
EISBN: 978-3-318-02738-9
...]. Somatostatin Receptor Imaging Somatostatin receptor (SSTR) imaging (SRI) can be accomplished by scintigraphy using a gamma camera or, more recently, by PET. SRI facilitates tumor staging and, compared to CT, additional lesions are generally diagnosed. It is also mandatory to perform SRI in order to obtain...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452910
EISBN: 978-3-318-06014-0
... activity, and inhibition of vascular calcification and regulation of smooth muscle cell function [ 5 , 6 , 7 , 18 ]. These specific functions seem to be dependent on the 2 residues (P and K) immediately adjacent to Cys-Cys loop and to the binding to a receptor(s) other than sstr, including ghrelin receptor...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/isbn.978-3-318-02773-0
EISBN: 978-3-318-02773-0
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000402936
EISBN: 978-3-318-02773-0
... in a particular tumor is not clinically identified prior to initiation of therapy [ 4 ]. Only radioisotope-based somatostatin receptor (SSTR) therapy (PRRT) implies the identification and quantification of the target (SSTR) prior to the administration of treatment [ 22 ]. In general, PRRT is well tolerated...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
10.1159/000403885
EISBN: 978-3-318-02773-0
... is an unmet need because molecular markers play a critical role in developing personalized therapies. Moreover, it is important to emphasize the best therapeutic approaches so far, which are extensively described in the references [ 1 , 2 , 3 ]. NET Therapeutic Targets Somatostatin receptors (SSTRs...
Book Chapter
Series: Frontiers in Diabetes
Volume: 22
Published: 10 April 2014
EISBN: 978-3-318-02598-9
... receptors (SSTRs) in neuroendocrine tumors. Front Biosci 2008;13:822-840. 39. Schonbrunn A: Selective agonism in somatostatin receptor signaling and regulation. Mol Cell Endocrinol 2008;286:35-39. 40. Hofland LJ, Visser-Wisselaar HA, Lamberts SW: Somatostatin analogs: clinical application...
Book Chapter
Series: Frontiers in Diabetes
Volume: 22
Published: 10 April 2014
10.1159/000357244
EISBN: 978-3-318-02598-9
... addition to the medical therapy of Cushing's disease is, at present, unknown. ACTH-secreting pituitary adenomas express somatostatin receptors (SSTR), mainly subtype 5 (SSTR5), but also subtypes 1 and 2 (SSTR1 and 2) [ 27 ]. Activation of SSTR5 specifically suppresses ACTH - and thereby cortisol...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318507
EISBN: 978-3-8055-9445-5
... The rationale for this treatment is the presence of somatostatin receptors (SSTRs) in human corticotroph adenomas, with the subtypes 1, 2 and 5 being the most frequently found; both SSTR2 and 5 seem to be implicated in the regulation of ACTH release, but SSTR5 is considered to be the predominant receptor [ 37...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 20
Published: 12 April 1996
10.1159/isbn.978-3-318-03666-4
EISBN: 978-3-318-03666-4
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 35
Published: 21 June 2006
10.1159/isbn.978-3-318-01379-5
EISBN: 978-3-318-01379-5
Book
Book Cover Image
Series: Progress in Basic and Clinical Pharmacology
Volume: 10
Published: 24 January 1996
10.1159/isbn.978-3-318-04091-3
EISBN: 978-3-318-04091-3
Book Chapter
Series: Frontiers of Hormone Research
Volume: 44
Published: 11 August 2015
EISBN: 978-3-318-02773-0
... 2008;286:40-48. 71. Florio T: Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors. Front Biosci 2008;13:822-840. 72. Florio T, Morini M, Villa V, Arena S, Corsaro A, Thellung S, Culler MD, Pfeffer U, Noonan DM, Schettini G, Albini...
Book Chapter
Series: Frontiers in Diabetes
Volume: 20
Published: 24 November 2009
10.1159/000262665
EISBN: 978-3-8055-9276-5
... an angiostatic effect [ 2 ]. In addition, an SST deficit in the vitreous fluid and a lower expression in the retina have been found in diabetic patients [ 26 , 27 ]. Furthermore, a significantly worsened neovascularization has been detected in a model of transgenic mice lacking the SST receptor type 2 (SSTR-2...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318497
EISBN: 978-3-8055-9445-5
... of phenotypic variation observed in the 3 IFS relatives harboring the Y268X AIP mutation, we further sequenced the genes encoding the somatostatin receptors 2 and 5 ( SSTR2 and SSTR5 ). These genes are involved in somatostatin-mediated GH suppression, and SSTR 5 variants have been associated with higher GH...