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Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317163
EISBN: 978-3-8055-9596-4
... Abstract Two novel methods for genome wide selection (GWS) were examined for predicting the genetic merit of animals using SNP information alone. A panel of 1,546 dairy bulls with reliable EBVs was genotyped for 15,380 SNPs that spanned the whole bovine genome. Two complexity reduction methods...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317167
EISBN: 978-3-8055-9596-4
... diseases in humans and are, therefore, suitable candidate genes for inflammatory disease resistance in cattle. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the bovine TLR2 and CARD15 and evaluate the association of these SNPs with health and production traits...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317169
EISBN: 978-3-8055-9596-4
...) alleles were 0.914 and 0.086, respectively, where the VV genotype had lower frequency than expected. Polymorphisms were also observed at codons 137, 143 and 173 of exon-3. scrapie PRNP gene SSCP SNP Gaddi sheep ...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317180
EISBN: 978-3-8055-9596-4
... problems associated with leg and bone disorders, the pig has been suggested to be a good model for human bone disorders. Hence, the present study examined 134 porcine genes affecting skeletal development, mineral metabolism and other candidate genes for single nucleotide polymorphism (SNP) discovery...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317279
EISBN: 978-3-8055-9596-4
... Abstract In genome-wide association studies using single nucleotide polymorphisms (SNPs), typically thousands of SNPs are genotyped, whereas the number of phenotypes for which there is genomic information may be smaller. A two-step SNP (feature) selection method was developed, which consisted...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362464
EISBN: 978-3-318-02700-6
... the potential for direct functional impact on the disease. Consequently, it has become common to name these loci according to the gene that maps closest to the lead SNP (i.e. that with the strongest association signal), unless there are more compelling nearby biological candidates, such as HHEX/IDE...
Book Chapter
Series: Forum of Nutrition
Volume: 60
Published: 17 August 2007
10.1159/000107078
EISBN: 978-3-318-01499-0
... Abstract There are many genetic variations in the human genome. The most abundant form ofgenetic variation is the single nucleotide polymorphism (SNP). SNPs are thought to beresponsible for observable differences in biological processes among individuals of a population.Genetic association...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317162
EISBN: 978-3-8055-9596-4
... Abstract Availability of a dense single-nucleotide polymorphism (SNP) map in chickens has allowed for whole-genome QTL mapping for disease resistance. In this study, two F8 advanced intercross lines of broiler by Fayoumi and broiler by Leghorn chickens, and a dense, genome-wide SNP panel were...
Book Chapter
..., antithrombin and factor V Leiden.More recently, attention has shifted to frequent single-nucleotide polymorphisms (SNPs) in coagulationgenes. First, SNPs in candidate genes were tested in case-control studies and documented the associatedrisk. For several SNPs the intermediate phenotype, in the form...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317168
EISBN: 978-3-8055-9596-4
... Abstract Haptoglobin (Hp) is an acute phase protein that is a marker in blood for clinical and subclinical disease in the pig. The aim of this study was to identify single nucleotide polymorphisms (SNPs) in the Hp gene and analyse their influence on baseline serum levels. DNA samples and serum...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317189
EISBN: 978-3-8055-9596-4
... Abstract The sequencing of genomes, such as that of the cow, has led to the discovery of thousands of single nucleotide polymorphisms (SNPs). By combining this knowledge with new methods that can genotype thousands of SNPs efficiently, it has become possible to carry out genome-wide association...
Book Chapter
Series: Medicine and Sport Science
Volume: 61
Published: 16 June 2016
10.1159/000445237
EISBN: 978-3-318-03011-2
... and the significance of this 99.9% identity statistic have been disputed by experts in genomics for many years. Real genetic differences between two randomly selected healthy humans would include not only substitutions of one letter for another in the genetic code (single-nucleotide polymorphisms, SNPs, and rare...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317144
EISBN: 978-3-8055-9596-4
... to Salmonella infection with a variety of Salmonella serovars and infection models. To map disease resistance genes, we are using a combination of expression quantitative trait loci (eQTLs) from microarray studies, allied with whole genome SNP arrays (WGA) and a candidate gene approach. There are over 500...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317179
EISBN: 978-3-8055-9596-4
... Abstract Toll-like receptor 4 (TLR4) is the key receptor for the LPS component of Gram-negative bacteria. We have identified a SNP within the 5’ UTR region of the bovine TLR4 gene at position 226 (c.-226C>G) relative to start codon, which was found to be associated with health related...
Book Chapter
Series: Medicine and Sport Science
Volume: 61
Published: 16 June 2016
10.1159/000445239
EISBN: 978-3-318-03011-2
... ], and the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) [ 5 ]. Focusing first on the HERITAGE white participants, the GWAS identified 39 single-nucleotide polymorphisms (SNPs) associated with VO 2 max adaptation to the 20-week exercise training program. A set of 21 SNPs...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317171
EISBN: 978-3-8055-9596-4
... polymorphisms (SNPs), distributed along the MHC sequence were genotyped. Correlation between VNTR marker alleles and serology was studied in more than 800 animals and correspondence between SNP haplotypes and allele size was defined. A complete table of correspondence between VNTR allele sizes, SNP genotypes...
Book Chapter
Series: Advances in Biological Psychiatry
Volume: 30
Published: 19 October 2015
10.1159/000438468
EISBN: 978-3-318-05584-9
... step to 5-hydroxytryptophan. To find genetic risk factors for suicidal behavior, early studies concentrated on single nucleotide polymorphisms (SNPs) in these genes. A first meta-analysis [ 22 ] did not find an association of the commonly studied intron 7 A218C (TPH1) SNP with suicidal behavior per se...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321235
EISBN: 978-3-8055-9644-2
.... Basically, genetic variability (e.g. single nucleotide polymorphism (SNPs), deletions/insertions or copy number variants) are tested for association with a (clinical) phenotype, in an unbiased open approach. However, GWAS have several limitations. First, it is often unclear if the ‘genetic tag...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 101
Published: 03 May 2010
10.1159/000314512
EISBN: 978-3-8055-9428-8
.../Nutrigenomics The first challenge for developing clinical nutrigenetics/nutrigenomics is the growing misconception that only very large studies can develop evidence for associations between single nucleotide polymorphisms (SNPs) and phenotypes. The use of genome-wide profiling of common single nucleotide...
Book Chapter
Series: Medicine and Sport Science
Volume: 61
Published: 16 June 2016
10.1159/000445240
EISBN: 978-3-318-03011-2
... candidate loci contributing to the trait of interest [ 14 ]. Thus, GWASs facilitated by high-throughput genotyping technologies have been enormously successful in identifying single-nucleotide polymorphisms (SNPs) that are associated with complex traits. DNA polymorphisms (with the frequency...