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Book Chapter
Series: Monographs in Human Genetics
Volume: 21
Published: 11 September 2017
10.1159/000477282
EISBN: 978-3-318-06098-0
... of histone modification profiles and the chromatin remodeling. Following successful fertilization, the epigenetic signatures of the paternal genome are altered during the early embryonic stages compatible with the embryonic developmental program that begins a new life cycle. We highlight the remodeling...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 62
Published: 12 August 2008
10.1159/000146259
EISBN: 978-3-8055-8554-5
.... Such riskbasedstratification strategies are also increasingly being used in the treatment of childrenwith solid tumors. In addition, genomic technologies are now being used to identifynew molecular markers or signatures for both diagnostic and prognostic purposes.Recently we reported the analysis of pediatric osteosarcoma...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381162
EISBN: 978-3-318-05457-6
... to frailty, further work is needed to determine whether overall microbial signatures of frailty exist and, if so, what the diagnostic and therapeutic utility of these signatures might be. Our Resident Microbes: Numerous, Diverse and Differentiated The human microbiome is a collective term...
Book Chapter
Series: Advances in Biological Psychiatry
Volume: 29
Published: 23 May 2014
10.1159/000358178
EISBN: 978-3-318-02600-9
... focused on the identification of proteomic signatures able to discriminate patients from controls, even leading to the proposal of diagnostic tests for mental disorders; however, no major attempts have been made to fulfill the clinical need for signatures able to predict response to antidepressants...
Book Chapter
Series: Current Problems in Dermatology
Volume: 55
Published: 29 November 2021
10.1159/000517592
EISBN: 978-3-318-06608-1
.... The mutagenic effects of UV radiation depend on DNA damage following direct absorption by nuclear DNA, resulting in cyclobutane pyrimidine dimers and pyrimidine (6–4) pyrimidone photoproducts that, if not repaired by nucleotide excision repair pathway, result in characteristic UV signature mutations (C→T or CC...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 31
Published: 06 February 2018
10.1159/000467378
EISBN: 978-3-318-06059-1
... or a predictive value, differentiation of which is often difficult as both can coexist. At present, MGMT promoter methylation is considered as a predictive marker for response of glioblastoma to chemotherapy with temozolomide, particularly in elderly patients, 1p/19q co-deletion is a molecular signature...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 33
Published: 22 January 2018
10.1159/000481103
EISBN: 978-3-318-06202-1
... signature and for which clinical response to macrostimulation does not play a critical role. We will discuss the rationale and principles of this new technique as well as its advantages and disadvantages relative to awake, physiologically guided deep brain stimulation surgery. Introduction Deep...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 30
Published: 14 December 2017
10.1159/000464376
EISBN: 978-3-318-06057-7
... of effectiveness of the adjuvant therapy and timely identification of recurrence, and even insights into molecular signatures of the neoplasms. Therefore, advanced neuroimaging is one of the most important cornerstones of the modern neuro-oncology. Introduction Development of advanced radiological...
Book Chapter
Series: Monographs in Human Genetics
Volume: 21
Published: 11 September 2017
10.1159/000477284
EISBN: 978-3-318-06098-0
... this information from mice to humans. Nevertheless, mouse models greatly enhance our understanding of fertility pathways, which is critical in order to identify genes and epigenetic signatures involved in the pathophysiology of male reproductive disorders and offspring health. This review will provide prominent...
Book Chapter
Series: Medicine and Sport Science
Volume: 62
Published: 19 June 2017
10.1159/000470919
EISBN: 978-3-318-06044-7
...-of-the-art molecular methods, collectively known as “omics”, e.g., proteomics (proteins) and metabolomics (metabolites), in order to identify new and even more robust molecular signatures of blood manipulation that can be used in combination with the ABP and, intriguingly, even as a stand-alone test...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 78
Published: 19 April 2016
10.1159/000442135
EISBN: 978-3-318-05802-4
... on the identification of characteristic molecular signatures and genomic alterations in specific histologic subtypes. Using a molecular biological approach, several signalling pathways have been identified in many cancers of salivary gland origin; thus, a number of targeted therapies have been investigated...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 78
Published: 19 April 2016
10.1159/000442139
EISBN: 978-3-318-05802-4
..., the primary tumor characteristics that predict DM include the primary tumor site, tumor stage and grade, perineural spread, cervical nodal status, and genomic signatures. The most common site of DM is the lung, followed by the bone, liver, and brain. Depending on the clinical presentation, DM can be treated...
Book Chapter
Series: Advances in Biological Psychiatry
Volume: 29
Published: 23 May 2014
10.1159/000358024
EISBN: 978-3-318-02600-9
... of the present review is to depict the most significant studies that have defined signatures of metabolic markers for the diagnosis of schizophrenia. These analyses were performed on various categories of samples including cerebrospinal fluid, blood (i.e. plasma/serum), erythrocytes, urine and postmortem brain...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 29
Published: 23 September 2013
10.1159/000351932
EISBN: 978-3-318-02464-7
... studies. These genes have been shown to partially interact with each other as well as with environmental factors to shape the overall disease risk in a complex genetic model. Additionally, recent studies have pointed out the crucial role of epigenetic signatures such as methylation patterns in modifying...
Book Chapter
Published: 17 August 2012
10.1159/000336343
EISBN: 978-3-8055-9930-6
... Abstract The biopsychosocial signatures for stress-related conditions are age, sex, and gender specific. The trajectories of these diseases are furthermore dynamic as they manifest themselves differently throughout lifespan development and in the context of broader social, cultural...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328270
EISBN: 978-3-8055-9791-3
... BAP1 , mapping to 3p21.1, in class 2 tumors. Among other discriminant genes identified from genome-wide expression profiling, PTP4A3 , mapping to 8q24.3, coding for a protein promoting cell migration, is highly overexpressed in class 2 tumors. The overall expression signature of class 2 tumors...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318496
EISBN: 978-3-8055-9445-5
... sequence similarities in their C-termini, which contains their signature sequences of Ankyrin repeats, SH3 domain and proline-rich region. Recent investigations reported that the expression of iASPP mRNA and protein was increased in non-transformed cells induced to undergo apoptosis and inhibition of iASPP...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 24
Published: 12 February 2009
10.1159/000197891
EISBN: 978-3-8055-9016-7
... disease, no clear signature pattern of cerebral atrophy associated with DLB has beenestablished so far. Among others, one reason may be the difficulty in visualizing the small brainnuclei that are differentially involved among the dementias. While we think that structural magneticresonance imaging...
Book Chapter
... isolationmethods may significantly enrich for the desired cell population and reduce the time required for cellexpansion. MSC have got both unique biological properties and a unique molecular signature, whichclearly discriminate them from other stem cell types. They express a strong immunomodulatory activityand...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 21
Published: 27 March 2006
10.1159/000092438
EISBN: 978-3-318-01284-2
... Abstract Significant new developments in neurovascular ultrasound include molecular approachesto diagnostics and therapy. Addition of targeted ligands to microbubbles, has opened newavenues for the identification of vascular injury. This is because the molecular signatures ofoverexpressed...