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Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522449
EISBN: 978-3-318-07054-5
... analysis of the power spectrum of blood pressure (BP) signals. I remember vividly that on examination of our very first batch of results from approximately 20 patients, I noted immediately that despite sustained BP, the spectral signals in the lower frequency range (0–0.15 Hz) were missing from some...
Book Chapter
Series: Monographs in Human Genetics
Volume: 19
Published: 07 March 2011
10.1159/000318841
EISBN: 978-3-8055-9595-7
... Abstract The cranial sutures act as the growth centers for the flat bones of the skull. They regulate the growth of these bones, but also prevent their premature fusion, known as craniosynostosis, to allow for the growth of the brain. In the past 15 years or so, many of the signaling pathways...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 11
Published: 18 February 2010
10.1159/000289197
EISBN: 978-3-8055-9384-7
...-limiting controls to modify the abundance of the TNF mRNA and the rate of its translation in response to environmental signals. Mechanistically, these controls consist of signaling networks converging to RNA-binding proteins and microRNAs, which in turn target a code of secondary or tertiary ribonucleotide...
Book Chapter
Series: Forum of Nutrition
Volume: 63
Published: 10 December 2009
10.1159/000264399
EISBN: 978-3-8055-9301-4
... Abstract The physiological regulation of adiposity is supposed to depend on endocrine ‘adiposity signals’ that inform the brain about the mass of the adipose tissue. Basal levels of insulin and leptin are widely accepted to be adiposity signals, and amylin, ghrelin and peptide YY have been...
Book Chapter
Series: Monographs in Virology
Volume: 27
Published: 11 August 2008
10.1159/000151657
EISBN: 978-3-8055-8502-6
... mediated by different intracellularsignaling cascades that regulate a variety of events in the infected cell including expression of cellularantiviral genes and cytokines. The relevance of these signaling responses for the pathogenicity of avianinfluenza viruses was recently highlighted by the fact...
Book Chapter
Series: Contributions to Nephrology
Volume: 152
Published: 09 October 2006
10.1159/000096318
EISBN: 978-3-318-01393-1
... to the identification of transporterbinding partners such as protein kinases and phosphatases, cytoskeletal elements andlipids. Considerable progress has also been made recently in understanding the upstream elementsin volume sensing and volume-sensitive signal transduction, and salient features ofthese systems...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 88
Published: 11 August 2005
10.1159/000087834
EISBN: 978-3-318-01233-0
... factor, LIF), each factor utilizing at least one pathwayfor intracellular signaling in the trophoblast. Two pathways that are crossed especiallyoften mediate the signals of these factors and are simultaneously well established in terms oftumor invasion: the Janus kinase-signal transducers and activators...
Book Chapter
Series: Current Directions in Autoimmunity
Volume: 8
Published: 28 October 2004
10.1159/000082087
EISBN: 978-3-318-01165-4
... Abstract Cell-surface CD19 functions as a general rheostat for defining intrinsic and antigenreceptor-induced signaling thresholds critical for clonal expansion of the B cell pool andhumoral immunity. CD19 also governs B cell responses initiated through the CD21 receptor,where complement C3d...
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Series: Current Directions in Autoimmunity
Volume: 5
Published: 19 December 2001
10.1159/isbn.978-3-318-00773-2
EISBN: 978-3-318-00773-2
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