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Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506566
EISBN: 978-3-318-06734-7
... was latterly proven to be correct by Oscar Minkowski. More than 130 years later SGLT inhibitors were introduced into diabetes treatment. After the introduction of the first SGLT inhibitor in the USA, the FDA received notice that following SGLT inhibition cases of severe ketoacidosis occurred. Sadly, the FDA...
Book Chapter
Series: Frontiers in Diabetes
Volume: 27
Published: 18 June 2019
10.1159/000486263
EISBN: 978-3-318-06507-7
..., such as dipeptidyl peptidase 4 (DPP-4) inhibitors, sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, were used. There are 5 large randomized clinical trials that examine the impact of intensive glycaemic control on cardiovascular events in diabetes (Table 1...
Book Chapter
Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/000439372
EISBN: 978-3-318-05639-6
... in further clinical advantages for DPP-4 inhibitors is the subject of current further research. Sodium-Glucose Transporter-2 Inhibitors Sodium-glucose transporter (SGLT)-2 inhibitors are a novel drug class that was approved for the treatment of type 2 diabetes in 2012. SGLT-2 is a specific sodium...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506563
EISBN: 978-3-318-06734-7
..., that important “discoveries” were made by obscure others way before bold announcements or, alternatively, that not much had been discovered after all. For example, the ketogenic effects of the plant extract phlorizin, later transformed into modern SGLT inhibitors, was described by von Mering in 1887, before...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
EISBN: 978-3-318-06734-7
..., Minkowski O: Diabetes mellitus nach Pankreasexstirpation. Arch Exp Path Pharm 1890;26:371–387. 10. Joslin EP: Pathology of diabetes mellitus. Boston Med Surg J 1894;130:330–334. 11. Jörgens V: The roots of SGLT inhibition. Laurent Guillaume de Koninck, Jean Servais Stas and Freiherr Josef von Mering...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
EISBN: 978-3-318-06734-7
... of SGLT inhibition: Laurent-Guillaume de Koninck, Jean Servais Stas and Freiherr Josef von Me­ring. Acta Diabetol 2019;56:29–31. ...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 124
Published: 15 June 2022
10.1159/000516731
EISBN: 978-3-318-06296-0
... a meal or ingestion of oral rehydration solution (Fig.  1 ). The carrier specific for Na-glucose co-transportation, Na-glucose co-transporter 1 (SGLT-1), is preserved in most diarrheal diseases and forms the basis for oral rehydration therapy [ 1 , 10‒13 ]. In fasted states or between meals, most NaCl...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 113
Published: 17 April 2015
10.1159/000367869
EISBN: 978-3-318-02691-7
... interaction between endocrine, paracrine, immune, and enteric nervous systems • Cotransportation of Na + with glucose by SGLT-1 is preserved in most diarrheal diseases and forms the basis for the oral rehydration solution • Breastfed infants, including low-birth-weight infants, in hot climates do...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506549
EISBN: 978-3-318-06734-7
...” was the beginning of the use of SGLT inhibition in diabetes care over 100 years later [ 11 ]. In contrast to von Mering, Minkowski continued diabetes research throughout his career. In the first years after the discovery of pancreatic diabetes he had to reply to numerous voices of criticism, particularly...
Book Chapter
Series: Endocrine Development
Volume: 32
Published: 21 August 2017
10.1159/000475737
EISBN: 978-3-318-05974-8
... proves to be inadequate as the disease progresses, especially with increasing body weight. Add-on treatments are commonly employed to supplement metformin, and sodium-glucose cotransporter 2 (SGLT-2) inhibitors have emerged as an attractive complement. In particular, dapagliflozin when used...
Book
Book Cover Image
Series: Frontiers in Diabetes
Volume: 27
Published: 18 June 2019
10.1159/isbn.978-3-318-06507-7
EISBN: 978-3-318-06507-7
Book
Book Cover Image
Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/isbn.978-3-318-05639-6
EISBN: 978-3-318-05639-6
Book
Book Cover Image
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/isbn.978-3-318-06734-7
EISBN: 978-3-318-06734-7
Book
Book Cover Image
Series: Frontiers in Diabetes
Volume: 19
Published: 12 August 2008
10.1159/isbn.978-3-8055-8641-2
EISBN: 978-3-8055-8641-2
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506558
EISBN: 978-3-318-06734-7
... to the present day and provided for the development of glucagon-like peptide-1 (GLP-1) enhancers and receptor agonists as well as sodium glucose transporter-2 inhibitors (SGLT-2i). The later class of drugs were developed after their basic physiologic effects were known to potentially ameliorate some...
Book Chapter
Series: Contributions to Nephrology
Volume: 169
Published: 14 January 2011
10.1159/000313944
EISBN: 978-3-8055-9538-4
... membrane is mediated by another family of glucose transporters (GLUT), which are Na + - independent and transport glucose by facilitated diffusion. In the early proximal tubule, GLUT2 is responsible for basolateral glucose transport, whereas GLUT1 is the main transporter in the late proximal tubule. SGLT...
Book
Book Cover Image
Series: Endocrine Development
Volume: 32
Published: 21 August 2017
10.1159/isbn.978-3-318-05974-8
EISBN: 978-3-318-05974-8
Book
Book Cover Image
Series: World Review of Nutrition and Dietetics
Volume: 124
Published: 15 June 2022
10.1159/isbn.978-3-318-06296-0
EISBN: 978-3-318-06296-0
Book
Book Cover Image
Published: 07 August 2008
10.1159/isbn.978-3-8055-8632-0
EISBN: 978-3-8055-8632-0
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 54
Published: 17 December 2021
10.1159/isbn.978-3-318-06791-0
EISBN: 978-3-318-06791-0