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Book Chapter
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 105
Published: 01 October 2012
10.1159/000341280
EISBN: 978-3-318-02228-5
... Abstract The effect of nutritional support in critically ill patients with sepsis has received much attention in recent years. However, many of the studies have produced conflicting results. As for all critically ill patients, nutritional support, preferably via the enteral route, should...
Book Chapter
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517701
EISBN: 978-3-318-06937-2
... Abstract Clinical Background: Clinical infections and its most severe forms sepsis and septic shock are commonly associated with changes in kidney function. This acute kidney injury (AKI) is associated with increased risk of morbidity and mortality in hospitalized patients. Epidemiology...
Book Chapter
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000323983
EISBN: 978-3-8055-9711-1
... Abstract Sepsis is still a serious threat, especially to patients hospitalized in intensive care units (ICUs). Despite advances in modern technology that lead to an improved outcome in individuals suffering from sepsis, clinicians must be cautious when the septic condition is suspected. Changes...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324009
EISBN: 978-3-8055-9711-1
... Abstract In cancer, therapies are targeted at 6 important pathways. In sepsis, there is ongoing controversy regarding the number and relative roles of pathways that are activated or repressed and which are important in the progression from health to death. Adding to complexity...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315914
EISBN: 978-3-8055-9485-1
... Abstract The word ‘sepsis’ is a descriptive term that denotes the clinical syndrome resulting from the activation of an innate host response to infection. Sepsis is a useful concept that underlines the fact that the morbidity of serious infection arises through the response of the host, rather...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527708
EISBN: 978-3-318-07124-5
... Abstract In the fields of sepsis and systemic inflammation, endotoxin might be the most studied molecule since the term was coined by Richard Pfeiffer in 1892. Paradoxically measuring endotoxin in humans and finding an effective treatment for endotoxemia have remained challenging. While...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527573
EISBN: 978-3-318-07124-5
... Abstract Sepsis is a life-threatening syndrome initiated by a dysregulated host response to infection. Maladaptive inflammatory burst damages host tissues and causes organ dysfunction, the burden of which has been demonstrated as the paramount predictor of worse clinical outcomes...
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527648
EISBN: 978-3-318-07124-5
... Abstract Sepsis is caused by the host response to an infectious organism. It is common among hospitalized patients and is associated with significant morbidity and mortality. The current standard of care for sepsis is predominantly supportive, with early detection followed by prompt antibiotic...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324022
EISBN: 978-3-8055-9711-1
... Abstract Sepsis is characterised by a hyper-inflammatory response due to microbial infection. We here review our current understanding of host mechanisms employed to mediate this hyper-inflammatory response, drawing together current knowledge pertaining to pathogen recognition and host pro...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324024
EISBN: 978-3-8055-9711-1
... Abstract Over the past two decades, it has become well accepted that sepsis exhibits two, oftentimes concomitant, inflammatory stages; a pro-inflammatory phase, referred to as the systemic inflammatory response syndrome (SIRS), and an anti-inflammatory phase, called the compensatory anti...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315915
EISBN: 978-3-8055-9485-1
... Abstract Endotoxin, or more accurately termed bacterial lipopolysaccharide (LPS), is recognized as the most potent microbial mediator implicated in the pathogenesis of sepsis and septic shock. Yet despite its discovery well over a century ago, the fundamental role of circulating endotoxin...
Book Chapter