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senescent

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Book Chapter
Series: Current Problems in Dermatology
Volume: 47
Published: 26 February 2015
10.1159/000369403
EISBN: 978-3-318-02775-4
..., histopathology, relevant blood tests) and management of male baldness, diffuse baldness and senescent alopecia. Introduction Male baldness is a genetically determined condition that is clearly an androgen-dependent trait [ 1 , 2 , 3 ]. Although in general, this condition is socially accepted as a natural...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 38
Published: 18 January 2013
10.1159/000343572
EISBN: 978-3-318-02307-7
... Abstract Cancer is a devastating disease that increases exponentially with age. Cancer arises from cells that proliferate in an unregulated manner, an attribute that is countered by cellular senescence. Cellular senescence is a potent tumor-suppressive process that halts the proliferation...
Book Chapter
Series: Contributions to Nephrology
Volume: 149
Published: 10 May 2005
10.1159/000085542
EISBN: 978-3-318-01222-4
... Abstract Hemodialysis treatment induces mononuclear cell activation particularly if cellulosichemodialysis membrane is used. In normal cells, repeated activation induce a process ofaccelerate cellular senescence. The aim of the present study was to evaluate whether themononuclear cell...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 42
Published: 29 November 2016
10.1159/000448542
EISBN: 978-3-318-05946-5
... repertoire is questionable and may be simply due to an inflammatory milieu widely observed with aging [ 61 ]. This situation may be at least partly maintained by the senescence associated secretory phenotype (SASP) [ 71 , 72 , 73 ]. This idea gains credibility with the acceptance of the notion that T cells...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358896
EISBN: 978-3-318-02653-5
... specify the effects of bottlenecks on longevity, and these were confirmed in two series of experiments. Commitment to senescence may be the loss of telomerase, which leads to the erosion of telomeres and the inability to grow indefinitely. Many experiments have been done with skin fibroblasts from human...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318489
EISBN: 978-3-8055-9445-5
... Abstract As commonly encountered pituitary adenomas are invariably benign, we examined protective pituitary proliferative mechanisms. Cellular senescence is characterized by a largely irreversible cell cycle arrest and constitutes a strong anti-proliferative response, which can be triggered...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 36
Published: 16 June 2008
10.1159/000137676
EISBN: 978-3-8055-8523-1
... Abstract Menopause and reproductive senescence can be more fully understood by examining these phenomenawhere they occur in nonhuman mammals, as well as humans, and especially by comparisons among primates.In addition to concerns about human health and welfare, successful programs for wildlife...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000382054
EISBN: 978-3-318-05478-1
... that cellular senescence is an underlying mechanism of aging and age-related conditions. Cellular senescence is a process in which cells lose the ability to divide and damage neighboring cells by the factors they secrete, collectively referred to as the senescence-associated secretory phenotype (SASP). Herein...
Book Chapter
Series: Current Problems in Dermatology
Volume: 56
Published: 05 July 2023
10.1159/000529557
EISBN: 978-3-318-07040-8
... constant throughout life. The basic pattern established early in embryonal life when facial segments expand and fuse is confounded by overlapping linearities of different backgrounds. Embryonal skin and skin in childhood, puberty, adult life and senescence undergo a general change in the direction...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
10.1159/000328117
EISBN: 978-3-8055-9793-7
... collectively termed growth plate senescence. Current evidence suggests that growth plate senescence occurs because the progenitor chondrocytes in the resting zone have a limited replicative capacity which is gradually exhausted with increasing cell division. In addition, recent experimental findings from...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358899
EISBN: 978-3-318-02653-5
... Abstract Cell senescence is one of the major paradigms of aging research. It started with the demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed cells, not shown by transformed malignant cells, this processes being largely regulated by the telomere...
Book Chapter
Book Chapter
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
EISBN: 978-3-318-02653-5
...): Telomerase, Aging and Disease. Adv Cell Aging Dis 2001;8:185-198. 6. Campisi J: Cellular senescence as tumor-suppressor mechanism. Trends Cell Biol 2001;11:27-31. 7. Campisi J: Review. Senescent cells, tumor suppression and organismal aging. Good citizens, bad neighbors. Cell 2005;120:513-522. 8...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 38
Published: 18 January 2013
EISBN: 978-3-318-02307-7
... microenvironment after transplantation of neoplastically transformed rat liver epithelial cells into the liver. Cancer Res 1997;57:1807-1813 7. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636 8. Dimri GP, et al: A biomarker that identifies senescent...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
EISBN: 978-3-318-05478-1
..., Ferreira M, Condel L, et al: Cellular senescence in aging primates . Science 2006;311:1257. 12. Dimri GP, Lee X, Basile G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo . Proc Natl Acad Sci U S A 1995;92:9363-9367. 13. Dumont P, Burton M, Chen QM...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 83
Published: 02 November 2015
10.1159/000430966
EISBN: 978-3-318-05478-1
..., and cellular senescence appear to contribute to the clinical presentation of frailty. This chapter summarizes the papers presented on the biological basis of frailty from the 83rd Nestlé Nutrition Institute Workshop on ‘Frailty, Pathophysiology, Phenotype and Patient Care' held in Barcelona, Spain, in March...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
EISBN: 978-3-318-02653-5
... 1982;141:325-332. 7. Schneider EL, Fowlkes BJ: Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis. Exp Cell Res 1976;98:298-302. 8. Ryan JM: The kinetics of chick cell populations aging in vitro. J Cell Phys 1979;99:67-78. 9...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358898
EISBN: 978-3-318-02653-5
... Abstract The observation that human fibroblasts have a limited number of cell population doublings in vitro led to the proposal that it is the expression of cellular aging. In vitro, the proliferation of human fibroblasts terminates with a postmitotic cell which was called senescent cell. Due...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
EISBN: 978-3-8055-9445-5
.... Science 1964;143:976 7. Sharpless NE, DePinho RA: Telomeres, stem cells, senescence, and cancer. J Clin Invest 2004;113:160-168 8. Serrano M, Blasco MA: Putting the stress on senescence. Curr Opin Cell Biol 2001;13:748-753 9. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW: Oncogenic ras...