... Abstract Respiratory syncytial virus (RSV) primarily infects upper respiratory tract cells, mainly nasal epithelial cells. The tight junctions of nasal epithelial cells are thought to perform important innate immune function against foreign materials including respiratory viruses. We...

... Abstract Respiratory syncytial virus (RSV) causes infection throughout life, with infants, adults who are severely immunocompromised, and the elderly at special risk of developing lower respiratory tract disease, hospitalisation, and death. The burden of severe disease in the elderly...

... virus (RSV) and rhinovirus, among many other pathogenic microorganisms [ 1 ]. Nasopharyngeal tonsils (adenoids) are believed to play crucial roles in OME pathogenesis during childhood through the modulation of innate and acquired immunity in the upper airway mucosal tissue [ 1 , 2 ]. The adenoids...

... Abstract Several respiratory viruses have been shown to cause exacerbations of asthma. While thevarious viral responses likely have common mechanisms of activation, the respiratory syncytialvirus (RSV) appears to promote specific responses that on their own can cause severe pulmonaryproblems...

... syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group. Pediatrics 1998;102:531–537. 29. Green CA, et al: Humoral and cellular immunity to RSV in infants, children and adults. Vaccine 2018;36:6183–6190...

... stability, and increased antigen homogeneity. Structural vaccinology is being applied in the rational design of a respiratory syncytial virus (RSV) vaccine, for which the correct conformation of the vaccine antigen proved essential for its impact [ 51 ]. RSV is a common infection in older adults...

... that suggests that TLR3 mediates the immune response to influenza A infection ( 42 , 43 ). Respiratory syncytial virus (RSV) is also a significant contributor to asthma exacerbations and is responsible for bronchiolitis in young children and also infects susceptible adults such as the elderly...

...: Advances in RSV vaccine research and development – a global agenda. Vaccine 2016;34:2870–2875. 55. Tappero JW, Lagos R, Ballesteros AM, et al: Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile. JAMA 1999;281:1520–1527. 56. Gerke C...

... and that immune responses are frequently developing slower in older adults. There are still many pathogens which cause significant morbidity and mortality in the older population but for which vaccines are currently not available. Respiratory syncytial virus (RSV) can cause severe lower respiratory tract...

... syncytial virus (RSV), which is a major causative agent of severe lower respiratory tract disease in infants and young children, induced miR-146a expression in an infection model of HNECs (unpubl. data). Thus, it is possible that manipulation of miR-146a presents a potential drug delivery system via...

... abbreviation “MIH” were minimal, with average relative search volumes (RSV) of 0 and 2, respectively. In contrast, more common dental conditions such as “tooth decay,” “toothache,” and “gingivitis” captured significantly higher public attention, with their mean RSVs reaching 21, 67, and 44, respectively...

... and their class II cytokine receptor IL-28R. Nat Immunol 2003;4:63-68. 12. Kotenko SV: IFN-λs. Curr Opin Immunol 2011;23:583-590. 13. Lambert L, Sagfors AM, Openshaw PJ, Culley FJ: Immunity to RSV in early-life. Front Immunol 2014;5:466. 14. Wine TM, Alper CM: Cytokine responses in the common cold...

.... A previous formalin-inactivated respiratory syncytial virus (RSV) vaccine was associated not with protection from RSV infection, but with exacerbated immunological response to infection which was detrimental ( 24 ). In an animal model, coadministration of MPL with this vaccine attenuated T-helper type 2 (Th2...