Search Results for rpe

... Abstract The majority of retinal pigment epithelial (RPE) tumors are considered to be congenital and benign. They are classified as either congenital hypertrophy of the RPE (CHRPE) or RPE hamartoma. CHRPE most frequently presents as an isolated, flat, darkly pigmented and well-delineated fundus...

... as an intraretinal vascular proliferation from the retinal deep capillary plexus (DCP) with initially no visible connection to the retinal pigment epithelium (RPE) and sub-RPE space or the choroid. In particular, the presence of hyper-reflective foci (HRF) detected on structural OCT has been considered as precursors...

... Abstract Suspensions of human embryonic stem cell-derived retinal pigment epithelium (hES-RPE) and human fetal RPE resurface aged and age-related macular degeneration (AMD) Bruch's membrane to a limited degree at day 21 in organ culture. Survival and differentiation of hES-RPE and human fetal...

... Abstract The retinal pigment epithelium (RPE) is a monolayer of cells adjacent to the photoreceptors of the retina. It plays a crucial role in maintaining photoreceptor health and survival. Degeneration or dysfunction of the RPE can lead to photoreceptor degeneration and as a consequence...

... to the forefront of the field of regenerative medicine. Retinal progeny derived from either pluripotent stem cells or tissue-specific retinal and retinal pigment epithelium (RPE) stem cells have the capacity both to replace damaged retina and to provide trophic support that slows disease progression. In contrast...

... explores the development of stem cell-based treatments for age-related macular degeneration (AMD), a prevalent ocular disease in the elderly. Retinal pigmented epithelium (RPE), a cell type implicated in AMD, has been derived from both induced pluripotent stem cells and embryonic stem cells (ESC). Rapidly...

... retinal pigment epithelium (RPE) cells. LF accumulation, originating from incomplete degradation of photoreceptor outer segment disks, represents a hallmark of RPE cell ageing. Excessive accumulation of LF granules in the lysosomal compartment of RPE cells signifies a downstream pathogenic pathway...

... of the retinal pigment epithelium (RPE) limited their application. A systematicreview of the literature up to July 2007 was performed using Medline (http://www.ncbi.nlm.nih.gov/PubMed/) where we specifically searched for relevant information regarding the laboratory as well as clinicaluse of PB and BBG...

... including oxidative damage to retinal pigment epithelium (RPE) cells, complement deposition in the RPE-Bruch's membrane-choriocapillaris complex, lipidization of Bruch's membrane, and extracellular matrix abnormalities (e.g. collagen crosslinking, advanced glycation end product formation). Antiangiogenic...

... viability test. Since the submicron parylene-C itself is difficult to handle, we design a mesh-supported submicron parylene membrane (MSPM) to provide sufficient mechanical support. This MSPM can support the growth of retinal pigment epithelial (RPE) cells in a monolayer with well-polarized morphology...

... with age [1]. The non-exudative (dry) and the exudative or neovascular (wet) form (nAMD) are the two main types of AMD [2]. AMD always begins as the dry form of the disease, and dry AMD is a slow degenerative process resulting in the loss of macular photoreceptors, retinal pigment epithelium (RPE...

... Abstract Dry age-related macular degeneration (AMD) is characterized by changes in the outer retina, retinal pigment epithelium (RPE), and choroid. Optical coherence tomography angiography (OCTA) has proven instrumental in analyzing these changes and further understanding the pathogenesis...

... = ganglion cell layer; ELM = external limiting membrane; IPL = inner plexiform layer; IS = photoreceptor inner segment; INL = inner nuclear layer; OS = photoreceptor outer segment; RPE = retinal pigment epithelium; IS/OS = interface between IS and OS. The outer retinal layers of the normal eye show...

... image quality, with a high inter- and intraobserver reproducibility but without automatic measuring software. Choroidal thickness (CT) is defined as the distance between the outer borders of the RPE to the hyper-reflective line of the choroid/sclera boundary at predefined intervals of the inner surface...

... of intraretinal type 3 NV that was agnostic of vascular origin (retinal vs. choroidal) [4]. Yannuzzi et al. [3] proposed that RAP lesions originated from deep retinal vessels with progression towards the sub-retinal pigment epithelium (RPE) space and anastomosis with the choroidal vasculature. In contrast, Gass...

... damage. Biochemical and histological studies of AMD eyes also indicate that oxidative damage plays a role in AMD pathogenesis. For example, Shen et al. [ 7 ] demonstrated DNA strand breaks and lipoperoxidation in eyes with geographic atrophy. RPE antioxidant enzyme changes in AMD eyes indicate...

... Abstract Macular edema is a major cause of morbidity in uveitis patients. Inflammatory mediators act on the integrity of the blood ocular barrier and on the function of the RPE pump. Chronicity leads to irreversible changes and is reported to cause up to 30% of permanent visual loss in uveitis...

... limiting membrane (fig. 1 ). Light must traverse these many layers before initiating signal transduction in the rods and cones. Below the photoreceptors resides the retinal pigment epithelium (RPE), a monolayer of cuboidal cells containing many melanosomes from which the cells derive their pigmented color...

... pigment epithelium; RPE) [2]. The choriocapillaris plexus (CC) is the vascular layer restricted to the innermost part of the choroid, located between Bruch’s membrane and the medium-sized choroidal vessels. The CC is unique in that it is fenestrated mostly on the retinal side. The latter hallmark...

... of the leading causes of vision loss in people over 60 years of age in the developed world. Dry AMD accounts for 85-90% of all cases of AMD [ 1 , 2 ]. In its early stages, it is characterized by the presence of drusen and pigmentary abnormalities resulting from alterations in the retinal pigment epithelium (RPE...