Search Results for role

... Abstract Introduction: Endoscopic endonasal approach (EEA) plays a central role in the treatment of GH-secreting pituitary adenomas (PAs)/pituitary neuroendocrine tumors (PitNETs), allowing to treat not only micro- or regular macro- PAs/PitNEts, but also more complex cases, otherwise...

... through premature maturation. Where individuals are diverted from the standard trajectory, for instance through caesarean section delivery, antibiotic exposure or other factors, supplemental probiotics may have a role in supporting appropriate early establishment of keystone species such as Bifidobacteria...

... and improve blood pressure and urine output in critically ill patients [ 3, 4 ]. Accordingly, our group reported relevant results on the role of polymethyl methacrylate (PMMA)–based continuous veno-venous hemofiltration in an animal model of sepsis-induced AKI. In this model, PMMA treatment improved...

... outcomes of this strategy. Introduction The omega-3 ( n -3) long-chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid and docosahexaenoic acid (DHA) together with the related omega-6 ( n -6) LCPUFA arachidonic acid (AA) are felt to play important roles with respect to brain...

... mechanistic insights in this process are sparsely reported. Understanding how stress exposure in early-life influences brain development, and understanding the role of nutrition in this process, is essential for the development of effective (nutritional) therapies to improve long-term health in children...

... for the cellular and molecular mechanisms of brain stem death began with the pro-life and pro-death roles of nitric oxide (NO) in the RVLM. NO was first identified as a gas by Joseph Priestly in 1772 [ 1 ], and for a long time since its discovery has been thought of simply as an atmospheric pollutant. It became...

... [ 7 ]. Subsequent biochemical work by Tissières et al. [ 8 ] led to multiple studies on the nature of heat stress and its biological role. In general, cells respond to extreme conditions by exhibiting an upregulation of HSP expression, which contributes to repair and protective mechanisms [ 6, 9...

... that most proteins in the cytosol and nucleus of eukaryotic cells are degraded via the ubiquitin-proteasome system (UPS), in an energy-dependent, highly complex, temporally controlled, and tightly regulated process that plays a major role in a variety of basic cellular processes during life and death...

... (see Chapters 4, 7, and 8), are among the many transcription factors that are sumoylated. Subsequent experiments from our group confirmed that sumoylation of HIF-1α and NF-κB in the rostral ventrolateral medulla (RVLM) plays a pro-life role during brain stem death. 9.1. Conjugation Like...

... features of metabolic syndrome in cancer survivors, analyzing in more detail patients treated with hormonal therapy and survivors of hematopoietic stem cell transplantation, who are burdened with a greater cardiovascular risk. Moreover, the role of lifestyle factors in the development of metabolic syndrome...

... Kidney and urinary problems are highly prevalent in our modern society and vary from simple acute symptoms to chronic complications with high mortality rates. Environment and life habits have been associated with higher risks of kidney disorders. Here, we focused on the hydration role in kidney health...

.... 2005;99(2):253–61. 27. Weaver YM, Ehresman DJ, Butenhoff JL, Hagenbuch B. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol Sci. 2010;113(2):305–14. 28. Han X, Nabb DL, Russell MH, Kennedy GL, Rickard RW. Renal...

... with an inability to consolidate sleep, a more complex phenotype that may result from secondary changes or be central to the role of hypocretin in coordinating the activity of other sleep- and wake-promoting systems. Novel technologies, such as the use of deep learning analysis of electroencephalographic signals...

...) are neuropeptides exclusively produced by neurons in the posterior hypothalamus that regulate various behavioral and physiological processes, including sleep-wakefulness and motivated drug taking. Given its dual role in sleep and addiction, the orexin system represents a promising therapeutic target for treating...

... and function of this system remain on an increasing trajectory. It is now clear that orexins play a significant role in mood and sleep regulation, and that OX 2 R may be more specifically involved in sleep-wake regulation. A dual receptor antagonist (DORA), suvorexant (BelsomraTM, Merck & Co. Inc...

... Abstract This paper provides an overview of the role of food systems in improving diets and addressing all forms of malnutrition, drawing on the experience of the Food and Agriculture Organization of the United Nations (FAO) and its partners. Firstly, it highlights the growing momentum for food...

... adjacent intracranial structures. With few exceptions, most of these tumors have a non-specific appearance on CT and MRI, which limits the role of imaging in terms of characterization. However, treatment planning (transnasal endoscopic surgery in particular) mostly depends upon the tumor map, exploiting...

... the last 2 decades, the role of an endoscopic approach to ASB surgery has been constantly expanding to encompass a range of pathologies and more advanced stages of sinonasal tumors involving the ASB [ 7 , 8 ]. Nevertheless, open ACFR still remains the gold standard surgical technique for extirpation...