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Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 99
Published: 18 April 2024
10.1159/000534951
EISBN: 978-3-318-07336-2
... through premature maturation. Where individuals are diverted from the standard trajectory, for instance through caesarean section delivery, antibiotic exposure or other factors, supplemental probiotics may have a role in supporting appropriate early establishment of keystone species such as Bifidobacteria...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000530476
EISBN: 978-3-318-07124-5
... ]. Accordingly, our group reported relevant results on the role of polymethyl methacrylate (PMMA)–based continuous veno-venous hemofiltration in an animal model of sepsis-induced AKI. In this model, PMMA treatment improved hemodynamic parameters and renal function, avoiding structural changes in the kidney...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519392
EISBN: 978-3-318-07015-6
... long-term developmental outcomes of this strategy. Introduction The omega-3 ( n -3) long-chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid and docosahexaenoic acid (DHA) together with the related omega-6 ( n -6) LCPUFA arachidonic acid (AA) are felt to play important roles...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519383
EISBN: 978-3-318-07015-6
... mechanistic insights in this process are sparsely reported. Understanding how stress exposure in early-life influences brain development, and understanding the role of nutrition in this process, is essential for the development of effective (nutritional) therapies to improve long-term health in children...
Book Chapter
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... for the cellular and molecular mechanisms of brain stem death began with the pro-life and pro-death roles of nitric oxide (NO) in the RVLM. NO was first identified as a gas by Joseph Priestly in 1772 [ 1 ], and for a long time since its discovery has been thought of simply as an atmospheric pollutant. It became...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... [ 7 ]. Subsequent biochemical work by Tissières et al. [ 8 ] led to multiple studies on the nature of heat stress and its biological role. In general, cells respond to extreme conditions by exhibiting an upregulation of HSP expression, which contributes to repair and protective mechanisms [ 6, 9...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522462
EISBN: 978-3-318-07054-5
... that most proteins in the cytosol and nucleus of eukaryotic cells are degraded via the ubiquitin-proteasome system (UPS), in an energy-dependent, highly complex, temporally controlled, and tightly regulated process that plays a major role in a variety of basic cellular processes during life and death...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522463
EISBN: 978-3-318-07054-5
... (see Chapters 4, 7, and 8), are among the many transcription factors that are sumoylated. Subsequent experiments from our group confirmed that sumoylation of HIF-1α and NF-κB in the rostral ventrolateral medulla (RVLM) plays a pro-life role during brain stem death. 9.1. Conjugation Like...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 54
Published: 17 December 2021
10.1159/000519414
EISBN: 978-3-318-06791-0
... features of metabolic syndrome in cancer survivors, analyzing in more detail patients treated with hormonal therapy and survivors of hematopoietic stem cell transplantation, who are burdened with a greater cardiovascular risk. Moreover, the role of lifestyle factors in the development of metabolic syndrome...
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517712
EISBN: 978-3-318-06937-2
... Kidney and urinary problems are highly prevalent in our modern society and vary from simple acute symptoms to chronic complications with high mortality rates. Environment and life habits have been associated with higher risks of kidney disorders. Here, we focused on the hydration role in kidney health...
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517711
EISBN: 978-3-318-06937-2
.... 2005;99(2):253–61. 27. Weaver YM, Ehresman DJ, Butenhoff JL, Hagenbuch B. Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths. Toxicol Sci. 2010;113(2):305–14. 28. Han X, Nabb DL, Russell MH, Kennedy GL, Rickard RW. Renal...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 45
Published: 27 May 2021
10.1159/000514959
EISBN: 978-3-318-06844-3
... with an inability to consolidate sleep, a more complex phenotype that may result from secondary changes or be central to the role of hypocretin in coordinating the activity of other sleep- and wake-promoting systems. Novel technologies, such as the use of deep learning analysis of electroencephalographic signals...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 45
Published: 27 May 2021
10.1159/000514965
EISBN: 978-3-318-06844-3
...) are neuropeptides exclusively produced by neurons in the posterior hypothalamus that regulate various behavioral and physiological processes, including sleep-wakefulness and motivated drug taking. Given its dual role in sleep and addiction, the orexin system represents a promising therapeutic target for treating...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 45
Published: 27 May 2021
10.1159/000514956
EISBN: 978-3-318-06844-3
... and function of this system remain on an increasing trajectory. It is now clear that orexins play a significant role in mood and sleep regulation, and that OX 2 R may be more specifically involved in sleep-wake regulation. A dual receptor antagonist (DORA), suvorexant (BelsomraTM, Merck & Co. Inc...
Book
Book Cover Image
Series: Frontiers of Neurology and Neuroscience
Volume: 45
Published: 27 May 2021
10.1159/isbn.978-3-318-06844-3
EISBN: 978-3-318-06844-3
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 121
Published: 01 December 2020
10.1159/000507495
EISBN: 978-3-318-06698-2
... Abstract This paper provides an overview of the role of food systems in improving diets and addressing all forms of malnutrition, drawing on the experience of the Food and Agriculture Organization of the United Nations (FAO) and its partners. Firstly, it highlights the growing momentum for food...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457923
EISBN: 978-3-318-06670-8
... adjacent intracranial structures. With few exceptions, most of these tumors have a non-specific appearance on CT and MRI, which limits the role of imaging in terms of characterization. However, treatment planning (transnasal endoscopic surgery in particular) mostly depends upon the tumor map, exploiting...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457925
EISBN: 978-3-318-06670-8
... the last 2 decades, the role of an endoscopic approach to ASB surgery has been constantly expanding to encompass a range of pathologies and more advanced stages of sinonasal tumors involving the ASB [ 7 , 8 ]. Nevertheless, open ACFR still remains the gold standard surgical technique for extirpation...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457927
EISBN: 978-3-318-06670-8
... locoregional control and reduce the frequency of distant metastasis, allowing longer survival for patients with unresectable disease. Here we discuss the evolving role of systemic therapy in the management of SNC. Locoregionally Advanced Disease Systemic therapy of SNC can be considered within...