... ] provided important support for the use of DNA-based mutation-detection assays for patient stratification by showing that mutations are transcribed into messenger (m)RNA in equal proportions to their allele frequency. Novel concepts are required to translate the comprehensive molecular cancer map...

... Abstract Targeting and downregulating specific genes with antisense and decoy oligonucleotides, ribozymes or RNA interference (RNAi) offer the theoretical potential of altering a disease phenotype. Here we review the molecular mechanism behind the in vivo application of RNAi-mediated gene...

... Abstract During the course of an infection, a pathogenic bacterium has to sense the environment and adjust its gene expression appropriately. One such environmental cue is the difference in temperature inside and outside the host. RNA thermosensors are structures that can respond to differences...

... Abstract Significant improvements have been made during the last 20 years in therapy of renaldiseases including the broadening of treatment options. Gene therapy is a potential modalityfor many renal diseases for which we are yet unable to offer specific treatment. Here, weintroduce RNA...