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rhgh

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Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439333
EISBN: 978-3-318-05637-2
... Abstract After the introduction of recombinant human growth hormone (rhGH) in 1985, a myriad of children and adults have benefited from its growth-promoting and metabolic effects. Nowadays, current therapeutic regimens rely on daily subcutaneous GH injections that could be burdensome...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341766
EISBN: 978-3-318-02245-2
... a dominant-negative 17.5 kD GH isoform that reduces the accumulation and secretion of wild type-GH ( wt -GH). At present, patients suffering from IGHD-2 are treated with daily injections of recombinant human GH (rhGH) in order to reach normal height. However, this type of replacement therapy, although...
Book Chapter
Series: Endocrine Development
Volume: 9
Published: 10 May 2005
10.1159/000085758
EISBN: 978-3-318-01215-6
... applies to patients with childhood-onset, severeGHD or with multiple hypopituitarism acquired in adulthood. The value of measuring IGF-Ilevels for monitoring the efficacy and the adequacy of rhGH replacement remains definitelyaccepted. ...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 106
Published: 12 February 2013
10.1159/000342529
EISBN: 978-3-318-02266-7
... of their disease management, the results of pituitary function tests need to be interpreted with caution [ 15 ]. There may be a role for growth-promoting agents including treatment with sex steroids and rhGH but these would generally only be considered in conjunction with IBD therapies in a short child who...
Book
Book Cover Image
Series: Endocrine Development
Volume: 1
Published: 11 December 1999
10.1159/isbn.978-3-318-00346-8
EISBN: 978-3-318-00346-8
Book Chapter
Series: Endocrine Development
Volume: 33
Published: 28 June 2018
10.1159/000487525
EISBN: 978-3-318-06143-7
... that discontinuing recombinant human growth hormone (rhGH) treatment causes an increase in fat mass and a decrease in muscle mass, reduction in bone mineral content and deterioration of the lipid profile [ 3 , 4 , 5 , 6 ]. Conversely, rhGH replacement is followed by an increase in muscle mass and a decrease in fat...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
EISBN: 978-3-318-02245-2
... in sports. Clin Chem 2009;55:445-453 29. Barroso O, Schamasch P, Rabin O: Detection of GH abuse in sport: Past, present and future. Growth Horm IGF Res 2009;19:369-374 30. Okano M, Nishitani Y, Sato M, Kageyama S: Effectiveness of GH isoform differential immunoassay for detecting rhGH doping...
Book Chapter
Series: Endocrine Development
Volume: 20
Published: 17 December 2010
10.1159/000321245
EISBN: 978-3-8055-9644-2
... (a) and height SDS/CA (b) with and without rhGH group over 3 years. Changes were compared between the two groups over 3 years. Changes in height SDS versus baseline (b) were significantly different between the two groups in the first year of the study (* p = 0.01...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 71
Published: 24 January 2013
10.1159/000342640
EISBN: 978-3-318-02270-4
.... Safety The era of pituitary-derived GH ended in the early 1980s when it was shown to be associated with Creutzfeldt-Jakob disease, a devastating and lethal neurodegenerative disorder. rhGH has been in use now for over 25 years and has an enviable track record of safety. To date, most safety data...
Book Chapter
Series: Medicine and Sport Science
Volume: 62
Published: 19 June 2017
10.1159/000460701
EISBN: 978-3-318-06044-7
..., the introduction of the blood module of the athlete biological passport greatly assists in detecting doping cases . Growth Hormone Commercially available recombinant human growth hormone (rhGH), a polypeptide, differs slightly from its human analog of pituitary origin. It is produced by recombinant...
Book
Book Cover Image
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/isbn.978-3-318-05637-2
EISBN: 978-3-318-05637-2
Book Chapter
Series: Frontiers in Diabetes
Volume: 22
Published: 10 April 2014
10.1159/000357242
EISBN: 978-3-318-02598-9
... in insulin-dependent diabetics before and after 7 days of treatment with 4 IU of recombinant human GH (rhGH). The insulin-dependent diabetics were subdivided into C-peptide-negative patients without endogenous pancreatic beta cell activity and C-peptide-positive patients with residual endogenous insulin...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 47
Published: 30 June 2016
10.1159/000445173
EISBN: 978-3-318-05869-7
... administration on body composition, depending on the population studied. In a group of obese post-menopausal women, the administration of rhGH alone and rhGH combined with rhIGF-1 led to increased fat-free mass, but rhIGF alone had no effect [ 34 ]. rhIGF-1 administration was associated with increased lean body...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452913
EISBN: 978-3-318-06014-0
... ]. A second important aspect of thymopoiesis modulated by the somatotrope axis is the thymocyte trafficking. Indeed, treatment with recombinant human GH (rhGH) enhanced engraftment of human and murine T cells in SCID mice recipient. This effect was due to a direct action on human T cells, since ovine GH...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341745
EISBN: 978-3-318-02245-2
... of the patients with IGF-1R defects have received rhGH treatment because they failed to show catch-up growth after being born small for gestational age. GH treatment of SGA children in general seems somewhat less effective compared to patients with GH deficiency even at higher doses. However, the growth response...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
EISBN: 978-3-318-05637-2
... and efficacy results of a 6 month, randomized, multi-center trial of a novel long-acting rhGH (VRS-317) in naïve to treatment, pre-pubertal children with growth hormone deficiency (GHD) (abstract). 16th International Congress of Endocrinology and the Endocrine Society's 96th Annual Meeting and Expo (ICE/ENDO...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358900
EISBN: 978-3-318-02653-5
... for the experimental approaches because species-identical sources of GH could not have been found for the experiments. Only by 1985 did it become possible to obtain recombinant human GH (rhGH). This technique allowed the use of true human GH, helping in the discovery of somatostatin analogues and the receptors...
Book
Book Cover Image
Series: Contributions to Nephrology
Volume: 100
Published: 30 September 1992
10.1159/isbn.978-3-318-03364-9
EISBN: 978-3-318-03364-9
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 14 September 2011
10.1159/000330469
EISBN: 978-3-8055-9860-6
...) in combination with recombinant human GH (rhGH) in 30 prepubertal children (M:F = 14:16) with osteogenesis imperfecta (OI) (types I, IV, and III) being treated with neridronate. Outcome measures included improvement of bone mineral density (BMD), projected bone areas, growth velocity, and fracture risk...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341736
EISBN: 978-3-318-02245-2
... stalk thickness is better evaluated than with conventional precontrast T 1 - and T 2 -weighted images and, in our experience, the sensitivity is similar to that of post contrast T 1 -weighted images. MRI and Height Response to rhGH Treatment. Evidence of congenital developmental abnormalities...