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Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
10.1159/000318502
EISBN: 978-3-8055-9445-5
... Abstract The RET receptor is a tyrosine kinase receptor implicated in kidney and neural development. In the adenopituitary RET and the co-receptor GFRa1 are expressed exclusively in the somatotrophs secreting GH. RET is implicated in a clever pathway to maintain at physiological levels...
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Book Chapter
Book Chapter
Book Chapter
Series: Endocrine Development
Volume: 26
Published: 15 September 2014
10.1159/000363165
EISBN: 978-3-318-02721-1
... with FMTC are usually identified by RET genetic screening shortly after birth or during childhood but they likely develop MTC later in adult life. A genotype-phenotype correlation has been observed between RET mutations and MEN2 syndromes. As for adults, the diagnosis of childhood MTC is based on serum...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 38
Published: 07 July 2010
EISBN: 978-3-8055-9445-5
...References References 1. Melmed S: Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 2003;112:1603-1618 2. Takahashi M, Ritz J, Cooper GM: Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 1985;42:581-588 3. Tahira T, Ishizaka Y...
Book Chapter
Series: Endocrine Development
Volume: 26
Published: 15 September 2014
EISBN: 978-3-318-02721-1
..., Niederle B, Zedenius J, Nordenskjold M, Komminoth P, Hendy GN, Mulligan LM, et al: The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET Mutation Consortium analysis. JAMA 1996;276:1575-1579. 4. Kloos RT, Eng C...
Book Chapter
Series: Developments in Ophthalmology
Volume: 60
Published: 24 April 2017
10.1159/000459690
EISBN: 978-3-318-06042-3
... will be describing some of the well known commercially available emerging simplified (Non Tabletop, Hand Held, Portable) retinal imaging tools that have potential to help in screening diabetic retinopathy with ease and without increasing financial burden. MII Ret Cam Make In India Retinal Camera (MII Ret Cam...
Book Chapter
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382101
EISBN: 978-3-318-05497-2
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452909
EISBN: 978-3-318-06014-0
... in the majority of cases, in about 20% of cases is due to a germline mutation in the rearranged during transfection (RET) proto-oncogene in the context of genetic syndromes (i.e. multiple endocrine neoplasia type 2, MEN2, and familial medullary TC). Instead, de novo RET/PTC translocations, BRAF, RAS, RET...
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Book Chapter
Book Chapter
Book Chapter
Series: Progress in Tumor Research
Volume: 41
Published: 19 February 2014
10.1159/000355902
EISBN: 978-3-318-02542-2
... according to the driver oncogenic mutation. Several novel driver oncogenic mutations, which are candidates as novel targets, such as ERBB2 , BRAF , ROS1 , and RET , have been discovered. Despite these successes, several limitations have arisen. One example is that some lung cancers do not respond...
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Series: Frontiers of Hormone Research
Volume: 28
Published: 29 May 2001
10.1159/isbn.978-3-318-00681-0
EISBN: 978-3-318-00681-0
Book Chapter
Series: Monographs in Clinical Cytology
Volume: 25
Published: 11 February 2020
EISBN: 978-3-318-06576-3
... of sarcomas: chromosomal translocations in sarcomas. Arch Pathol Lab Med 2006;130:1199–1207. 3. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al: RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012;18:378–381. 4. Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, et...
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