1-20 of 6209 Search Results for

resistance

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Book Chapter
Book Chapter
Book Chapter
Book
Book Cover Image
Series: Progress in Applied Microcirculation
Volume: 8
Published: 12 July 1985
10.1159/isbn.978-3-318-04067-8
EISBN: 978-3-318-04067-8
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494911
EISBN: 978-3-318-06471-1
... Abstract Hyperandrogenism with or without polycystic ovary syndrome can be sustained by an extreme form of insulin resistance (IR), and is thus a secondary form of hyperandrogenism, which may be due to a defect in insulin signal transduction or in the adipose tissue. Severe IR due to adipose...
Book Chapter
Series: Progress in Tumor Research
Volume: 44
Published: 07 May 2018
10.1159/000486986
EISBN: 978-3-318-06362-2
... hurdle. Here we give an overview of the different entities of the tumor microenvironment and present their role in radiation resistance. Dynamic changes in response to irradiation will be outlined, and relevant approaches to target critical elements of the tumor microenvironment will be discussed. We...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454739
EISBN: 978-3-318-06025-6
... Abstract Obesity is strongly associated with insulin resistance, diabetes mellitus, fatty liver disease, and dyslipidaemia. The opposite perturbation, namely absence or paucity of adipose tissue in lipodystrophy, leads to the same spectrum of disorders, often in an exaggerated form. The two...
Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454742
EISBN: 978-3-318-06025-6
... and small testes. An association between KS and type 2 diabetes has long been recognized, but the pathogenesis is still unknown. If both hypogonadism and visceral obesity play a role in the development of insulin resistance in men, KS offers an interesting window into this relationship. Indeed, in addition...
Book Chapter
Series: Current Problems in Dermatology
Volume: 52
Published: 15 March 2017
10.1159/000450777
EISBN: 978-3-318-05978-6
..., and HIV. The risk of infection depends on the following triad: microbial pathogen and its aggressiveness, individual resistance of the tattooed, and inoculation and exposures by the tattoo needle and in the tattoo parlor. Some infectious risks can be controlled. Persons with weaknesses can refrain from...
Book Chapter
Series: Endocrine Development
Volume: 26
Published: 15 September 2014
10.1159/000363159
EISBN: 978-3-318-02721-1
... Abstract Resistance to thyroid hormone (RTH) or thyroid hormone action defect (THAD) is the most frequent form of syndromes of reduced sensitivity to thyroid hormone. It is characterized by variable tissue hyposensitivity to thyroid hormone. RTHβ (formerly only RTH) is caused by mutations...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 74
Published: 18 July 2013
10.1159/000348463
EISBN: 978-3-318-02388-6
... deficiency was rare. Higher circulating concentrations of homocysteine predicted smaller baby size. Follow-up studies revealed that higher maternal folate in pregnancy predicted higher adiposity and insulin resistance in the child at 6 years of age, and that low maternal vitamin B 12 exaggerated the risk...
Book
Book Cover Image
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/isbn.978-3-318-02348-0
EISBN: 978-3-318-02348-0
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000343695
EISBN: 978-3-318-02268-1
...-Dudley syndrome (AHDS), and abnormal serum TH levels. AHDS thus represents a type of TH resistance caused by a defect in cellular TH transport. The normal thyroid produces predominantly the prohormone thyroxine (3,3’, 5,5'-tetraiodothyronine, T4) and only a small amount of the active hormone 3,3...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342494
EISBN: 978-3-318-02268-1
... Abstract End-organ resistance to the actions of parathyroid hormone (PTH) is defined as pseudohypoparathyroidism (PHP). Described originally by Fuller Albright and his colleagues in early 1940s, this rare genetic disease is subclassified into two types according to the nephrogenous response...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342496
EISBN: 978-3-318-02268-1
... characteristics of an internal/terminal exon and possesses stop codons triggering non-sense-mediated mRNA decay in LHCGR. When exon 6A is utilized, it results in a truncated LHCGR protein of only 209 amino acids that remains trapped intracellularly[ 2 ]. LH Resistance in Genetic Males Several homozygous...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342502
EISBN: 978-3-318-02268-1
... to reduced glucocorticoid sensitivity or resistance. Here, we summarize our current understanding of the mechanisms that modulate glucocorticoid sensitivity and resistance with a focus on GR-mediated signaling. Glucocorticoids are a class of stress-induced steroid hormones synthesized by the adrenal...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342504
EISBN: 978-3-318-02268-1
... Abstract ACTH resistance is a rare disorder typified by familial glucocorticoid deficiency (FGD), a genetically heterogeneous disease. Previously, genetic defects in FGD have been identified in the ACTH receptor gene (MC2R) , its accessory protein (MRAP) and the steroidogenic acute...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342505
EISBN: 978-3-318-02268-1
... Abstract Familial or sporadic primary generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids and a consequent hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis...
Book Chapter
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/000342511
EISBN: 978-3-318-02268-1
... resistance, diabetes, dyslipidaemia and fatty liver. Adipose tissue samples from affected patients revealed remarkably similar features to those previously observed in samples from obese insulin resistant patients, namely macrophage infiltration and fibrosis. Cellular mechanistic studies suggest...
Book
Book Cover Image
Series: Endocrine Development
Volume: 24
Published: 04 February 2013
10.1159/isbn.978-3-318-02268-1
EISBN: 978-3-318-02268-1