... Abstract The provision of continuous renal replacement therapy (CRRT) to pediatric patients presents numerous clinical and technical challenges that have been addressed over the past 40 years. Children provide an informative population for acute kidney injury and CRRT study, as pediatric...

.... In recent guidelines, the Endocrine Society conservatively advised against using GH during TKI treatment [ 27 ]. However, the guideline acknowledges that there is little evidence to inform this recommendation. Generally, GH replacement in cancer survivors should be managed in a manner similar to GH...

... Abstract Background: End-stage renal disease (ESRD) in children is considered a rare but serious condition. Information on the epidemiology, demographics, treatment modality at the start of renal replacement therapy (RRT), and mortality of pediatric patients with ESRD is essential...

..., is initiated. Estrogen replacement is important and natural 17β-estradiol, preferably transdermally, is the preferred choice, whereas the oral route can be used as an alternative depending on patient preference and compliance. Sexual activity is often delayed in the hypogonadal adolescent girl...

..., continuous venovenous hemofiltration replaced CAVH because of its improved performance and safety. From the initial adoptive technology, specific machines have been designed to permit safe and reliable performance of the therapy. These new machines have progressively undergone a series of technological steps...

... Abstract Renal replacement therapy (RRT) is increasingly utilized to support critically ill patients with severe acute kidney injury (AKI). The clinical dilemma of when to ideally start RRT in these patients has been a longstanding issue that is in need of higher quality evidence to guide...

... Abstract This chapter focuses on the definitions and impact of prescription and delivery of the right dose of treatment in patients on continuous renal replacement therapy (CRRT). We define “dose” and the concepts of efficiency, intensity, and efficacy; differentiate their multiple components...

... Abstract In the last 40 years, continuous renal replacement therapy (CRRT) has evolved from an initial modification of maintenance dialysis to a fully integrated component of modern multi-organ support. In CRRT, solute removal is mainly accomplished through diffusion and convection. Current...

... Abstract The most frequent indication for continuous renal replacement therapy (CRRT) is for fluid management - either to treat or prevent fluid overload. An association exists between exposure to positive or negative fluid balance (FB), compared with even FB, on one-year mortality and renal...

... Abstract Continuous renal replacement therapy (CRRT) has many potential indications that extend beyond the traditional removal of uremic waste products. Many of these stem from the capacity of CRRT to remove middle-sized molecules and its suitability for haemodynamically unstable patients...

... Abstract Continuous renal replacement therapy (CRRT) is commonly applied in critically ill patients affected by severe acute kidney injury for solute and volume control and to optimize acid-base and electrolytes balance. Although CRRT represents a life-saving procedure for these patients...

... Abstract The various complications of continuous renal replacement therapy (CRRT) are mostly preventable. Hemodynamic disturbances are dominated by hypotension due to the modification of volume status, myocardial dysfunction, cardiac arrhythmia, or modification of systemic vascular resistances...

... Abstract Renal replacement therapy (RRT) is a form of extracorporeal support for critical patients, especially for those with acute kidney injury. This therapy enables to gain adequate control over the great metabolic and fluids demand when kidneys are not able to do so; this condition...

... Abstract The continuous renal replacement therapy (CRRT) has offered life-saving treatment for kidney failure. Technological advances coupled with findings from clinical trials have allowed for refinements both in the therapy and in the way it is applied to patients. However, outcomes...

... Abstract Continuous renal replacement therapy (CRRT) is one of the most predominant forms of renal replacement therapy (RRT) currently in use now, this therapy being the initial RRT modality in most critically ill patients. However, in general, the quality of CRRT is still suboptimal...

... a variety of patients with severe cases due to major surgical interventions, trauma, hemodynamic instability, sepsis, and so on but also older people than previous times. All these situations can easily lead to MODS. In the prior years, the only available and efficient therapy was renal replacement therapy...

...-hydroxyvitamin D, but general screening has not been shown to improve health. One expert group has recommended a “reasonable” level of 30 ng/mL in those individuals for whom testing is required. Clear, practical guidance on vitamin D replacement should be derived from a strong evidence base on evaluation...

... been documented in patients undergoing continuous renal replacement therapy (CRRT) with heparin as an anticoagulant. Citrate has anticoagulation properties secondary to its ability to chelate calcium, which is necessary for the coagulation cascade. Citrate may thus be used in a regional anticoagulation...