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Book Chapter
Series: Current Problems in Dermatology
Volume: 55
Published: 29 November 2021
10.1159/000517637
EISBN: 978-3-318-06608-1
... at that time, in 1976, the EU legislator already took a conscious decision to treat and regulate sunscreens as fast-moving consumer products. Since then, the EU Cosmetics Directive/Regulation balances the need for strict safety and efficacy requirements, with need for rapid innovation and easy consumer...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 89
Published: 06 August 2018
10.1159/000486494
EISBN: 978-3-318-06352-3
... and modifiable predictors, including genetic and epigenetic characteristics, parental size, infant sex, psychosocial and other environmental conditions, infections and inflammation, hormonal regulation, and not least by nutrition and metabolism. Great preventive opportunities appear to exist through optimizing...
Book Chapter
Series: Endocrine Development
Volume: 29
Published: 22 December 2015
10.1159/000438840
EISBN: 978-3-318-02789-1
... coordinated changes in the output of a multiplicity of genes organized into functional networks. Recent evidence suggests that a dual mechanism of epigenetic regulation affecting the transcriptional activity of neurons involved in stimulating gonadotropin-releasing hormone release plays a fundamental role...
Book Chapter
Series: Frontiers of Oral Biology
Volume: 18
Published: 01 December 2015
10.1159/000351900
EISBN: 978-3-318-05480-4
... by sensory fibers that have either mechanoreceptors or nociceptors responsible to perceive mechanical pressure or pain, respectively, as well as supplied by autonomic fibers that are responsible to regulate blood flow in the periodontium [ 33 , 34 , 35 , 36 , 37 , 38 ]. Immunohistofluorescent staining...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382085
EISBN: 978-3-318-05497-2
... that become addicted to high levels of N-Myc protein can be selectively targeted. In untransformed neuronal precursor cells, N-Myc is regulated by a series of posttranslational modifications that lead to its proteasomal degradation during mitosis. Neuroblastoma cells harboring amplification of MYCN , however...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382099
EISBN: 978-3-318-05497-2
... ]. In humans, the importance of Tregs as immune regulators was recently demonstrated by the results of a pilot prospective study on a collective of 14 de novo NB patients at diagnosis [ 16 ]. The authors found that NB patients had a significantly higher baseline of Treg frequency compared to controls...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 29
Published: 09 September 2015
10.1159/000434674
EISBN: 978-3-318-02809-6
... with a brief summary of the development of technology for PNS and how regulatory issues have come into play. Next, device regulation in the US, Europe, Canada, and Australia is reviewed. Then, a review of the current and future state of PNS device regulation is provided. Readers should pay particular attention...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381381
EISBN: 978-3-318-05474-3
... Abstract Intestinal mononuclear phagocytes, comprising macrophages (Mϕs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381382
EISBN: 978-3-318-05474-3
... that TNF is critically involved in regulating T-cell lineage commitment and early thymocyte development. On the one hand, the role of TNF might consist of promoting the differentiation and the proliferation of T-cells. For that purpose, membrane-bound TNF seems to be responsible. Further, TNF seems...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381380
EISBN: 978-3-318-05474-3
... epithelial cell turnover, which is effectuated by cell shedding at the villus tip, the constant proliferation of stem cells, and the transient amplification of cells along the crypt-villus axis. This process involves highly coordinated regulation of the induction of cellular differentiation...
Book Chapter
Series: Current Problems in Dermatology
Volume: 48
Published: 24 March 2015
10.1159/000369228
EISBN: 978-3-318-02777-8
... in Italy, related legislation has not succeeded in keeping up with its development. This situation is common to many European countries and, in most cases, ‘strongly suggested directives' or ‘Guidelines' rather than specific regulations have been issued. The National Centre Organismo Notificato...
Book Chapter
Series: Current Problems in Dermatology
Volume: 48
Published: 24 March 2015
10.1159/000369231
EISBN: 978-3-318-02777-8
... Abstract The production of tattoo ink and pigments in the US is unregulated. There are no guidelines or standards issued by national agencies. However, the practice of tattooing is regulated at the state and local levels but varies widely. Adverse events are addressed when a problem is reported...
Book Chapter
Series: Progress in Respiratory Research
Volume: 42
Published: 13 March 2015
10.1159/000369322
EISBN: 978-3-318-02657-3
... political influence is presented. The chapter then outlines controversies about tobacco industry engagement in tobacco control before presenting three case studies of tobacco industry strategies to enhance profits and prevent regulation. The first case study describes tobacco companies' business...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 36
Published: 16 December 2014
10.1159/000366236
EISBN: 978-3-318-02791-4
... perfusion pressures, or CPPs), the CBF is kept constant. Above and below these limits, the mechanism does not evolve reasonably, entailing potentially harmful hypo- or hyperperfusion of the brain tissue. The regulation is based on cerebrovascular resistance (CVR) and is mainly adjusted in the small...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 79
Published: 10 September 2014
10.1159/000360685
EISBN: 978-3-318-02670-2
... Abstract The intestinal mucosa is the largest body surface exposed to the environment. While there are common features when comparing immune responses along the intestinal mucosa, the small bowel and colon exhibit striking differences in their mechanisms driving immune regulation. The vitamin...
Book Chapter
Book Chapter
Series: Monographs in Oral Science
Volume: 24
Published: 28 May 2014
10.1159/000358781
EISBN: 978-3-318-02596-5
...-mediated regulation of salivary glands should help in the development of strategies for preventing chronic oral dryness resulting from drugs or atrophic disease associated with inflammation and irradiation. Salivary glands fulfil a huge range of functions in different species, and even amongst...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358907
EISBN: 978-3-318-02653-5
... Abstract Regulation of longevity depends on genetic and environmental factors. According to Svanborg, a Swedish geriatrician, over the last decades human life expectancy increased as well as the age at onset of fatal diseases. Nevertheless, autopsies of centenarians revealed the presence...