... Abstract Intensive care patient nutritional therapy has been standardized by guidelines for decades. However, the same nutritional regimen to such a heterogeneous population seems a difficult task. These patients have various genotypes, numerous comorbidities, different severities and lengths...

... Abstract SummaryWe conducted a phase I trial in advanced non-small cell lung cancer in order to determine the optimal administration schedule for the 3-drug regimen carboplatin + etoposide + ifosfamide. This interim analysis shows that limiting toxicity (leukopenia) has been reached...

... Abstract SummaryTwelve patients with osteosarcoma previously treated with either a local recurrence alone or lung metastases alone or both received the combination of vindesine, ifosfamide and cis-platinum (HELP). They had received T 10-regimen, i. e. high-dose methotrexate in 7 cases...

... Abstract SummaryLong-term administration of vindesine, included in a maintenance regimen for acute lymphoblastic leukemia (ALL) with poor prognosis, proved to be effective. There was no apparent long-term cumulative neurotoxicity. ...

... by such testing. It has become popular to conceptualize personalized treatment regimens based upon tumor molecular profiling as “N of 1” trials. While appealing, the truth, of course, is that unless the intervention was given as part of an actual clinical trial, these cases are not clinical trials at all...