... Abstract IgA nephropathy (IgAN) is characterized by IgA immune complex-mediated mesangialcell proliferation. We have previously identified the transferrin receptor (TfR) as an IgA1receptor and found that, in kidney biopsies of patients with IgAN, TfR is overexpressed andco-localized with IgA1...

... Abstract The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled receptors, HCRTR1/OX 1 R and HCRTR2/OX 2 R. Shortly after the discovery of this system, degeneration...

... Abstract The androgen testosterone has an essential trophic role in the development of male physiology and in adult spermatogenesis and fertility. Testosterone mainly exerts its effect through the androgen receptor (AR), a ligand-activated transcription factor that is activated by binding...

... among adults. Among these, glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment appears to have reasonable weight loss efficacy along with other beneficial pleiotropic effects. Although larger trials will be required to confirm the results, two small pediatric clinical trials have suggested...

... to the interaction with the G-protein-coupled receptor 120 (GRP120), a lipid-sensing receptor highly expressed in activated macrophages. In fact, DHA may activate GPR120 expression in macrophages causing anti-inflammatory effects, and insulin-sensitizing and antidiabetic effects in vivo. Recently, it has been shown...

... Abstract Anaplastic lymphoma kinase (ALK) is a membrane-bound receptor tyrosine kinase that when aberrantly expressed is capable of promoting neuroblastoma pathogenesis, and serves as a bona fide therapeutic target. In this review, we discuss the physiologic role of ALK, the mechanisms...

... Abstract The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for capsaicin. Peripheral TRPV1 has a very well-described role...

... Abstract Peptide receptor radionuclide therapy (PRRT) has been a well-accepted and effective therapeutic modality for inoperable or metastatic gastroenteropancreatic, bronchopulmonary and other neuroendocrine tumors for almost 2 decades. In general, PRRT is well tolerated with moderate toxicity...

... Abstract Neuroendocrine tumors (NETs) produce various hormones and bioactive substances and are known to express a large variety of peptide hormone receptors. While these hormones and receptors play a role in the pathophysiology of this heterogeneous group of tumors, they also form an important...

... Abstract The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its correct function is required for normal skin development and homeostasis, while dysregulation of EGFR signalling results in cellular hyper-proliferation and defects in differentiation, leading to impaired...

... and extends over the last five decades. We recently identified soluble urokinase receptor (suPAR) as a circulating FSGS factor. Summary: suPAR represents the soluble form of a glycosylphosphatidylinositol-anchored membrane protein and has been implicated in a number of clinical conditions. With three...

... disease. Summary: The M-type phospholipase A 2 receptor-1 (PLA 2 R) has been identified as the major target antigen in primary MN. Approximately 70-80% of patients with clinically active MN have circulating anti-PLA 2 R autoantibodies, as detected by Western blot, ELISA, or immunofluorescence assay...