... Margaret L. Rand , Toronto, ON, Canada Shoshana Revel-Vilk , Jerusalem, Israel ...

... of the subendothelium; the platelet plug that forms aids in the cessation of bleeding. Asterisks indicate interactions involving VWF that occur at high shear. Reproduced with permission from Israels and Rand [ 3 ]. ADP, adenosine 5′-diphosphate; GP, glycoprotein; TxA 2 , thromboxane A 2 ; VWF, von Willebrand factor...

..., and Margaret L. Rand report no conflict of interest. Shoshana Revel-Vilk received grant/research support, honoraria, and advisory fee from Takeda, Pfizer, and Sanofi/Genzyme. Author Contributions Shoshana Revel-Vilk wrote the first draft of the chapter. Caroline Malcolmson critically revised the chapter...

.... Conflict of Interest Statement Margaret L. Rand has no conflicts of interest to declare. Sara J. Israels has no conflicts of interest to declare. Victor S. Blanchette reports receiving consultancy and speaker fees from Bayer HealthCare, Novo Nordisk, Pfizer, Roche, Takeda, and Spark Therapeutics. He...

... and Margaret L. Rand have no conflicts of interest to declare. Author Contributions Ahmad Al-Huniti drafted the appendix and submitted the final version. Rajiv K. Pruthi, Margaret L. Rand, Laura Avila, and Paul Monagle contributed to the design of the appendix, critically revised it, and approved...

...References References 1. Israels SJ, Kahr WH, Blanchette VS, Luban NL, Rivard G, Rand ML: Platelet disorders in children: a diagnostic approach. Pediatr Blood Cancer 2011;56:975 2. Rand ML, Israels SJ, McNicol A: Platelet structure and function;. in (eds) Israels SJ: Mechanisms...

..., Rand ML, Tosetto A, Silva M, James PD: Evaluation of the diagnostic utility for von Willebrand disease of a pediatric bleeding questionnaire. J Thromb Haemost 2009;7:1418 6. Biss TT, Blanchette VS, Clark DS, Bowman M, Wakefield CD, Silva M, Lillicrap D, James PD, Rand ML: Quantitation of bleeding...

...), Dr. Veerle Labarque (Leuven, Belgium), Dr. Margaret Rand (Toronto, Canada), Dr. Nancy Robitaille (Montréal, Canada), Dr. Claudio Solana (Buenos Aires, Argentina), and Dr. Alexandra Zabeida (Toronto, Canada) for providing insightful comments on the third version of this chapter. Conflict of Interest...

... J. Israels, Margaret L. Rand, and Yigal Dror for helpful insights during the reviewing process of this edition’s chapter. Conflict of Interest Statement Veerle Labarque reports receiving speaker and/or consultancy fees from Bayer, Novartis, NovoNordisk, Octapharma, Roche, Sobi, and Takeda...

... for the thoughtful comments provided by Margaret L. Rand for this edition. Conflict of Interest Statement Rungrote Natesirinilkul reports receiving consultancy and speaker fees from Sanofi-Genzyme, Novo Nordisk, Pfizer, Roche, Takeda, Grifols, and Novartis. He is a recipient of research grants from Novo...