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Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 77
Published: 30 September 2013
10.1159/000351398
EISBN: 978-3-318-02447-0
... Abstract There has been growing interest in the role of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) in the modulation of the immune response during early childhood and whether this may translate to a reduction in childhood allergic disease. Several randomized controlled trials of n-3...
Book Chapter
Book Chapter
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 102
Published: 08 August 2011
10.1159/000327789
EISBN: 978-3-8055-9780-7
... Advice to maintain or increase consumption of the omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) should be derived from interventional and observational trials evaluating the specific effects of dietary LA, rather than effects of n-3 PUFAs or total PUFAs. Failure to make...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 77
Published: 30 September 2013
10.1159/000351393
EISBN: 978-3-318-02447-0
... Abstract The lipid membrane bilayer undergoes continuous changes, and its lipid composition is both adaptive and highly varied, with substantial molecular variety. The balance of dietary fats, namely saturated versus unsaturated, and polyunsaturated fatty acids (PUFA) of the n-6 series versus...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 112
Published: 26 November 2014
10.1159/000365427
EISBN: 978-3-318-02753-2
... Abstract Long-chain polyunsaturated fatty acids (LC-PUFAs) influence a variety of cellular and physiological processes during the perinatal period by serving as membrane components, precursors of eicosanoids and docosanoids, and nuclear receptor activators. These processes include the growth...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 62
Published: 12 August 2008
10.1159/000146246
EISBN: 978-3-8055-8554-5
... Abstract Tissue availability of polyunsaturated fatty acids (PUFAs) is of major relevance forhealth, and it depends on both dietary intake and metabolic turnover. We found closeassociations between variants in the human genes of Δ5- and Δ6-desaturase, FADS1and FADS2, and serum phospholipid...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 112
Published: 26 November 2014
10.1159/000365608
EISBN: 978-3-318-02753-2
... of polyunsaturated fatty acids (PUFAs) is the most important characteristic of IVLEs. IVLEs rich in n-6 PUFAs may have a pro-inflammatory effect, whereas those rich in n-3 PUFAs may exert an anti-inflammatory effect. Other components to be considered are the risk of lipid peroxidation and the contents of α...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 124
Published: 15 June 2022
10.1159/000516721
EISBN: 978-3-318-06296-0
... and provide essential polyunsaturated fatty acids (PUFA) and lipid-soluble vitamins. Particularly during growth and development, the fat supply has an important impact on a variety of metabolic and physiological functions that are relevant for growth, tissue functions such as immune and neural functions...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 102
Published: 08 August 2011
10.1159/000327805
EISBN: 978-3-8055-9780-7
..., and some are thought to bear protective abilities, like vitamins D and E, selenium, lycopene, or unsaturated fatty acids, notably polyunsaturated omega-3 fatty acids (ω-3 PUFA) of marine origin [ 12 ]. Due to the inconsistent findings of the effect of polyunsaturated fatty acids on BrC and PCa...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 89
Published: 06 August 2018
10.1159/000486501
EISBN: 978-3-318-06352-3
... Abstract The long-chain polyunsaturated fatty acids (LC-PUFAs) docosahexaenoic acid (DHA) and arachidonic acid (ARA) occur in high levels in the brain and play a key role in brain growth and the operation of neurotransmitters. Infants supplemented with DHA show improved language...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 77
Published: 30 September 2013
10.1159/000351397
EISBN: 978-3-318-02447-0
... Abstract The current report provides a brief background introducing 30 years of research on long-chain polyunsaturated fatty acids (LC-PUFA) and infant development, but focuses mainly on challenges for future studies. Infants fed formulas containing only vegetable fats were found to have lower...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 112
Published: 26 November 2014
10.1159/000365605
EISBN: 978-3-318-02753-2
... in n-6 polyunsaturated fatty acids (PUFAs) were used as the lipid component of PN. There is some evidence that n-6 PUFAs may promote inflammation, which may increase surgical stress and worsen the outcome [ 3 , 4 ]. As a result, new generations of LEs have been developed that contain a reduced amount...
Book Chapter
Series: Key Issues in Mental Health
Volume: 181
Published: 15 January 2016
10.1159/000440922
EISBN: 978-3-318-05621-1
... of which are discussed in this chapter. First, based on the hypothesis of excessive apoptosis in emerging psychosis, neuroprotection has emerged as a target for treatment. Among neuroprotective substances, polyunsaturated fatty acids (PUFA) have received considerable attention. After trials in chronic...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 110
Published: 15 April 2014
10.1159/000358460
EISBN: 978-3-318-02641-2
... Abstract Lipids provide infants with most of their energy needs. The major portion of the fat in human milk is found in the form of triglycerides, the phospholipids and cholesterol contributing for only a small proportion of the total fat. Long-chain polyunsaturated fatty acids (LC-PUFAs...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 102
Published: 08 August 2011
10.1159/000327796
EISBN: 978-3-8055-9780-7
... fatty acids (n-3 PUFA). Cognitive Decline and Dementia Aging is an area of increasing interest stimulated by awareness of the rising proportion of older people and of the projected costs of pensions and health care, changing patterns of consumption and of lifestyles. In this context, slowing down...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 102
Published: 08 August 2011
10.1159/000327787
EISBN: 978-3-8055-9780-7
... Polyunsaturated fatty acids (PUFA), including omega-6 (n-6) and omega-3 (n-3) fatty acids, are essential nutrients that function as important modulators of multiple biological pathways that affect health and disease. n-6 and n-3 PUFA are metabolically and functionally distinct and often have...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439324
EISBN: 978-3-318-05637-2
.../GRP120 may play a key role in slowing the progression of liver damage in patients with NAFLD. During the last decade, ω-3 (n-3) polyunsaturated fatty acids (PUFAs) have received particular attention for their abilities to counteract inflammation, oxidative stress, angiogenesis and metastasis [ 1...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 102
Published: 08 August 2011
10.1159/000327800
EISBN: 978-3-8055-9780-7
... Nutrition’ of the French Agency. There are many FA involving multiple functions. Among the PUFAs, some are known as ‘essential’ precursors (linoleic, C18:2n-6 and α-linolenic, C18:3n-3 acids) because they are essential for growth and physiological functions, and cannot be synthesized by humans...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 112
Published: 26 November 2014
10.1159/000365431
EISBN: 978-3-318-02753-2
... esters. Direct uptake of the remnant particles takes place not only in the liver but also in extra-hepatic tissues and plays an important role in the delivery of some fatty acids (namely n-3 polyunsaturated fatty acids (PUFAs)) as well as tocopherols and other lipid-soluble vitamins. This process, which...