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pthrp

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Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491045
EISBN: 978-3-318-06409-4
...-mediated signal transduction pathway and, in particular, in the PTH/PTHrP signaling pathway: the main subtypes of PHP and related disorders are caused by de novo or autosomal dominantly inherited inactivating genetic mutations, and/or epigenetic, sporadic, or genetic-based alterations within or upstream...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491040
EISBN: 978-3-318-06409-4
... hormone (PTH)-related peptide (PTHrP) by a wide variety of nonmetastatic solid tumors, including squamous cell tumors but also hematologic tumors. PTHrP, although encoded by a distinct gene, shares amino acid sequence homology with PTH in the amino-terminal domain, which allows it to cross-react...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
10.1159/000328081
EISBN: 978-3-8055-9793-7
... an embryonic growth plate showing the different chondrocyte subpopulations. Growth factors (BMP, FGF, IHH, PTHrP and WNT5a) can activate (arrows) or inhibit (bars) the formation of distinct chondrocyte populations. Fig. 2. In the embryonic growth plates, distinct chondrocyte populations can...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
EISBN: 978-3-318-06409-4
... hormone-related peptide (PTHrP) secretion by gastroenteropancreatic neuroendocrine tumors (GEP-NETs): clinical features, diagnosis, management, and follow-up. J Clin Endocrinol Metab 2014;99:3060-3069. 12. Brzozowska MM, Wolmarans L, Conaglen JV: Hypercalcaemia caused by a carcinoid tumour. Intern Med...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
10.1159/000328084
EISBN: 978-3-8055-9793-7
... cellular architecture and kinetics of the growth plate requires both patterning and differentiating factors that act together to regulate the process of growth plate chondrogenesis. The understanding of these regulatory signals has increased substantially over the past few years. The role of PTHrP, IHH...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
EISBN: 978-3-8055-9793-7
..., Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM: PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 2002;129:2977-2986 3. MacLean HE, Kronenberg HM: Localization of Indian hedgehog and PTH/PTHrP receptor expression...
Book Chapter
Series: Endocrine Development
Volume: 16
Published: 17 June 2009
10.1159/000223691
EISBN: 978-3-8055-9162-1
... tumour, or because of inactivating mutations of the calcium-sensing receptor or because some other factor, such as vitamin D or PTHrP, causes hypercalcaemia independently of PTH. In the latter instance, PTH secretion is suppressed. It is often useful to get a clue to the aetiology by examining the urine...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/isbn.978-3-318-06409-4
EISBN: 978-3-318-06409-4
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
10.1159/000380998
EISBN: 978-3-318-05467-5
.... In addition, abnormalities in the vitamin D supply or metabolism may cause hypercalcaemia. PTH-related protein (PTHrP) occasionally causes hypercalcaemia, whereas calcitonin has little effect on systemic calcium homeostasis. Extracellular calcium homeostasis is required for normal muscle and nerve...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491034
EISBN: 978-3-318-06409-4
... the course of the disease, and its occurrence may signify an unfavorable prognosis [ 8 ]. Of the cases that result from malignancy, approximately 80% are due to the effects of PTH-related peptide (PTHrP), while the other 20% are due to bone metastases. Hypercalcemia secondary to malignancy may be classified...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 20
Published: 12 April 1996
10.1159/isbn.978-3-318-03666-4
EISBN: 978-3-318-03666-4
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
10.1159/000380988
EISBN: 978-3-318-05467-5
...-related peptide (PTHrP) and fibroblast growth factor 23 (FGF23), are directly involved in the control of mineral metabolism in man. In addition, several other hormones, such as oestrogens and androgens, cortisol, growth hormone and thyroxine, have modifying effects. The story of the unravelling...
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 14 September 2011
10.1159/000330548
EISBN: 978-3-8055-9860-6
... induced by loss of PTH/PTHrP receptor Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM Endocrine Unit, Massachusetts General Hospital and Harvard...
Book
Book Cover Image
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
10.1159/isbn.978-3-8055-9793-7
EISBN: 978-3-8055-9793-7
Book Chapter
Series: Yearbook of Pediatric Endocrinology
Published: 13 September 2010
10.1159/000320655
EISBN: 978-3-8055-9602-2
... Technologies). Results: In a large pedigree with BDE, short stature, and learning disabilities, the authors detected a microdeletion of approximately 900 kb encompassing PTHLH , the gene coding for parathyroid hormone-related protein (PTHRP). Mutation analysis performed in these individuals identified...
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
EISBN: 978-3-318-05467-5
... with idiopathic infantile hypercalcemia caused by mutation in CYP24A1 gene. Eur J Pediatr 2013;172:45-49. 39. Stewart AF: Clinical practice. Hypercalcemia associated with cancer. N Engl J Med 2005;352:373-379. 40. Niizuma H, Fujii K, Sato A, Fujiwara I, Takeyama J, Imaizumi M: PTHrP-independent...
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
10.1159/000380990
EISBN: 978-3-318-05467-5
... are involved in the maintenance of normal concentrations of calcium and phosphate in plasma. Plasma calcium is mainly influenced by PTH and the active form of vitamin D, 1α,25-dihydroxyvitamin D (1,25(OH) 2 D). In addition, calcitonin (CT) and parathyroid hormone-related peptide (PTHrP) play a more minor role...
Book Chapter
Series: Endocrine Development
Volume: 21
Published: 23 August 2011
EISBN: 978-3-8055-9793-7
... targeted disruption of the parathyroid hormone- related peptide gene. Genes Dev 1994;8:277-289 8. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Juppner H, Segre GV, Kronenberg HM: PTH/PTHrP receptor in early development and Indian...
Book
Book Cover Image
Series: Contributions to Nephrology
Volume: 91
Published: 02 October 1991
10.1159/isbn.978-3-318-03355-7
EISBN: 978-3-318-03355-7
Book
Book Cover Image
Published: 07 May 2002
10.1159/isbn.978-3-318-00778-7
EISBN: 978-3-318-00778-7