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Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491045
EISBN: 978-3-318-06409-4
... associated with Albright's hereditary osteodystrophy), as well as laboratory abnormalities consistent with hormone resistance, such as hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone (PTH) and thyroid-stimulating hormone levels. All these disorders are caused by impairments in the cAMP...
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Book Chapter
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Book Chapter
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Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491036
EISBN: 978-3-318-06409-4
... Abstract Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 50
Published: 20 April 2018
10.1159/000486060
EISBN: 978-3-318-06339-4
... parathyroid hormone (PTH) release. Hypocalcemia leads to the opposite sequence of events, namely, lowered intracellular calcium and increased PTH production and secretion. PTH rapidly increases renal calcium reabsorption and, over hours to days, enhances osteoclastic bone resorption and liberates both calcium...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 50
Published: 20 April 2018
10.1159/000486077
EISBN: 978-3-318-06339-4
... Abstract The interplay between vitamin D and parathyroid hormone (PTH) represents one of the most important metabolic mechanisms of regulation of the calcium/phosphorus homeostasis. Secondary hyperparathyroidism is therefore a major complication that arises as a result of reduced vitamin D...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491042
EISBN: 978-3-318-06409-4
... Abstract The regulation of plasma calcium levels is essential for the normal physiologic function of every cell. Parathyroid hormone (PTH) is the principal regulator of serum calcium and phosphate homeostasis. PTH is synthesized and secreted by the parathyroid chief cells in the parathyroid...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491041
EISBN: 978-3-318-06409-4
... of these patients, particularly when the autonomous THP develops, still require a surgical approach. One of the main tasks of parathyroid hormone (PTH) is that of maintaining a normal calcium homeostasis. In fact, it has long been recognized that even small changes in the serum levels of ionized calcium...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 49
Published: 26 April 2018
10.1159/000486003
EISBN: 978-3-318-06335-6
... Abstract Parathyroid glands are the main regulator of body mineral metabolism through parathormone (PTH) actions on bone and kidney. Experimental evidence suggests that PTH may have non-classical target organs such as adipose tissue, arterial vascular wall, cardiac muscle cells, and adrenal...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491047
EISBN: 978-3-318-06409-4
...(1-84) and PTH(1-34) in patients with chronic hypoparathyroidism. The research done in this field has shown that replacement treatment with rhPTH(1-84) is an important therapeutic option for subjects with chronic hypoparathyroidism who are not well controlled with conventional treatment. However...
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
10.1159/000380998
EISBN: 978-3-318-05467-5
... to the accompanying levels of parathyroid hormone (PTH), indicating whether the causes are PTH dependent or PTH independent. This chapter reviews the recent advances in this area and presents a practical approach to the investigation and subsequent management of this condition. Introduction Hypercalcaemia...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491034
EISBN: 978-3-318-06409-4
... Abstract The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus...