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proteolyticdegradation

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Book Chapter
Series: Advances in Cardiology
Volume: 42
Published: 04 May 2006
10.1159/000092573
EISBN: 978-3-318-01317-7
... were all recognized inthe diabetic heart. Such a deterioration in the expression of Cx43 was alleviated by treatmentwith either lysosomal (leupeptin) or proteasomal inhibitor (ALLN). These results suggestthat the PKCε-mediated hyperphosphorylation of Cx43 makes Cx43 vulnerable to proteolyticdegradation...