... Abstract Prostate cancer is a highly prevalent disease with a high likelihood of survival. If treated, survivors live with significant and lasting treatment-related side effects. Surgical treatment is associated with urinary incontinence and erectile dysfunction, and radiation leads to urinary...

... Abstract Prostate cancer is the most common cancer in men in the United States and is the second most common cause of death. While treatment options in early stage disease are curative in intent, treatment of metastatic prostate cancer remains challenging. Although, several new and promising...

... Breast (BrC) and prostate cancers (PCa) are the two most common tumors in women and men, respectively, in Western countries [ 1 , 2 ]. Both tumors are hormone-dependent cancers in their early stages. They share some similar risk factors like age, obesity, and genetic factors such as family...

... Abstract For several decades it has been assumed that higher testosterone (T) leads to greater growth of benign and malignant prostate tissue, but this view has come under greater scrutiny over the last several years. Although there are as yet no large-scale, long-term controlled studies of T...

... Abstract This review outlines the different treatment options in localized prostate cancer. This information canbe considered alongside other important factors, such as the individual patient’s values and situationas well as the potential impact of treatment on his quality of life...

... Abstract Radical prostatectomy for treatment of prostate cancer is a technically sophisticated operation. Simplertherapies have therefore been developed in the course of decades. The decisive advantage ofa radical operation is the chance of a cure with minimal collateral damage. It is the only...

... Abstract Several randomized trials have demonstrated that adjuvant medical or surgical castration may improveoverall survival in patients with locally advanced prostate cancer undergoing external beamradiotherapy. After radical prostatectomy, patients with positive lymph nodes seem to benefit...

... Abstract Although hormone therapy is widely used in the management of prostate cancer, the optimal timingof its initiation remains a matter of debate. Many studies of the last decades have reported a smallbut significant survival benefit and a clear delay in the development of clinical symptoms...

... Abstract Lymph node status in prostate cancer is not only of prognostic but also of tremendous therapeuticrelevance. In case of positive lymph nodes (N+), common standards demand the renunciation of localcurative therapy (such as radiotherapy or radical prostatectomy) and hormonal withdrawal...

... Abstract Some studies have shown that a number of patients with positive lymph nodes may be potentiallycurable. Seventy-five lymph node-positive prostate cancer patients were treated by radiotherapy alone(36%) or by radiotherapy after radical prostatectomy (64%). The prostatic region...

... forpatients with hormone-refractory prostate cancer. Several new treatments are under investigationin phase III trials and will further improve the treatment options for these patients within the nextyears. ...