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prostaglandin

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Book Chapter
Series: Translational Research in Biomedicine
Volume: 4
Published: 30 April 2015
10.1159/000375427
EISBN: 978-3-318-05445-3
... cytokine-induced secretion of prostaglandin E2 (PGE2). This inhibitory action has been associated with reduced expression of COX-2, without modulating COX-1 expression. This mechanism is associated with VA-induced destabilization of COX-2 mRNA, thereby depleting the functional COX-2 mRNA available...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338368
EISBN: 978-3-318-02184-4
... Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, decrease mucosal prostaglandin (PG) E 2 content by inhibiting cyclooxygenase (COX) activity and cause damage in the small intestine. The development of these lesions required the inhibition of both COX-1 and COX-2...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320819
EISBN: 978-3-8055-9567-4
...The target: Prostaglandin D2 and its receptor CRTH2 Prostaglandin D2 In tissues outside the central nervous system, production of prostaglandin D 2 (PGD 2 ) is restricted to cells involved in the allergic response and appears to be instrumental in orchestrating...
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