... Abstract Progressive neuroblastoma has a high risk of disease recurrence despite cancer treatment. Most patients can be identified at the time of diagnosis either by age over 18 months and the presence of distant metastases, or by amplification of the oncogene MYCN . As the body of knowledge...

... Abstract IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. About 25-30% of IgAN patients will progress to end-stage kidney disease in 20-25 years. Early-onset symptoms that are highly suggestive of progressive IgAN include massive proteinuria, hypertension, renal...

... Abstract Rapidly progressive glomerulonephritis (RPGN) is a life-threatening disease with a poor prognosis. In this review, the pathogenesis of RPGN owing to antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and anti-GBM diseases is discussed. By the model...

... Abstract Plasma exchange has been used for the treatment of rapidly progressive glomerulonephritis (RPGN) for more than 40 years. Its main application has been the rapid removal of special pathogenic factors that are of great importance for treatment of antiglomerular basement membrane disease...

... Abstract Progressive familial intrahepatic cholestasis is a group of inherited disorders that have been identified in the last two decades. Infants presenting with mild to severe jaundice, low GGT (FIC1, FIC2), elevated serum bile acids, failure to thrive and pruritus characterise PFIC...

... Abstract Backgrounds: Cyclophosphamide and high-dose steroids have been used as limitedinduction therapy in progressive IgA nephropathy (IgAN) to reduce the loss of renal functionand proteinuria. We evaluated the effect of cyclophosphamide pulses (CyP) and mycophenolicacid (MPA) as sequential...

... inhibit the progressive decline in renal function of patientswith progressive IgAN. Patients who had a marked linearity of decline in loss of glomerularfiltration rate (GFR), assessed by reciprocal serum creatinine plots vs. time for more thanone year, were recruited in this study if they were...