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Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... The observations that a biomarker of life and death undergoes augmentation followed by reduction and disappearance during the progression towards brain stem death in experimental animal models open the vista to search for both pro-life and pro-death cellular and molecular programs...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522464
EISBN: 978-3-318-07054-5
... for this classical tumorigenic signaling in brain stem death. Specifically, activation of PI3K/Akt signaling in the rostral ventrolateral medulla (RVLM) via an important upstream cofactor, FLJ10540 [ 15‒17 ], subserves a pro-death role in brain stem death by eliciting defunct cardiovascular regulation. At the same...
Book
Published: 10 November 1992
10.1159/isbn.978-3-318-06277-9
EISBN: 978-3-318-06277-9
Book Chapter
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... ]. Given that death posts the most severe threat to existence, we undertook a series of studies in early 2000s on HSPs, and found that at least HSP60 and HSP70 in the rostral ventrolateral medulla (RVLM) play a pro-life role during brain stem death. 6.1. Heat Shock Proteins as Molecular Chaperones...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522461
EISBN: 978-3-318-07054-5
... associated with brain stem death. We further found that the repertoire of oxygen-sensitive gene products activated by hypoxia in the RVLM during the pro-life phase of brain stem death may entail sequential activation of HIF-1, heme oxygenase-1 (HO-1), and heat shock protein 70 (HSP70), leading...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522463
EISBN: 978-3-318-07054-5
... (see Chapters 4, 7, and 8), are among the many transcription factors that are sumoylated. Subsequent experiments from our group confirmed that sumoylation of HIF-1α and NF-κB in the rostral ventrolateral medulla (RVLM) plays a pro-life role during brain stem death. 9.1. Conjugation Like...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 28
Published: 27 February 2013
10.1159/000343972
EISBN: 978-3-318-02311-4
... Abstract Throughout the last 20 years, numerous studies have indicated pro-inflammatory activity in patients with an acute schizophrenic episode. In this report, the most relevant findings concerning the cytokine systems in schizophrenia are demonstrated, together with recent studies on gene...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324022
EISBN: 978-3-8055-9711-1
... Abstract Sepsis is characterised by a hyper-inflammatory response due to microbial infection. We here review our current understanding of host mechanisms employed to mediate this hyper-inflammatory response, drawing together current knowledge pertaining to pathogen recognition and host pro...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324026
EISBN: 978-3-8055-9711-1
... time making the host more vulnerable for secondary infections). This chapter discusses key components of the pro- and anti-inflammatory response to sepsis and the regulation thereof. The assumption that sepsis is the consequence of an overwhelming inflammatory reaction of the patient...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324030
EISBN: 978-3-8055-9711-1
.... The completion of several, large prospective clinical trials should finally determine the safety, feasibility and efficacy of this strategy for severe sepsis [ 10 , 11 ]. Ovine Anti- TNF- α Polyclonal Fab Fragment (CytoFab) TNF-a is a potent and early pro-inflammatory cytokine released from myeloid cells...
Book
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Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/isbn.978-3-8055-9711-1
EISBN: 978-3-8055-9711-1
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