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Book Chapter
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457927
EISBN: 978-3-318-06670-8
... cancers (e.g., adenoid cystic carcinoma), sinonasal undifferentiated carcinoma (SNUC), and sinonasal neuroendocrine carcinoma (SNEC) are also reported [ 1 , 2 ]. Sinonasal primary mucosal melanoma, olfactory neuroblastoma (ONB), different types of sarcoma, hematolymphoid tumors, germ cell tumors...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 83
Published: 19 February 2019
10.1159/000492310
EISBN: 978-3-318-06389-9
... microsurgery (TLM) or transoral robotic surgery (TORS). Oncologic outcomes reported are comparable whatever modality is chosen, but better functional outcomes are observed in the RT/CRT and TLM/TORS-treated patients. Because of the high rate of second primary malignancies, which influences overall survival...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 83
Published: 19 February 2019
10.1159/000492316
EISBN: 978-3-318-06389-9
... analysis of multi-site head and neck trials and retrospective reviews [ 4 ]. Direct comparison between different treatment options is difficult due to the variable inclusion criteria, stages of disease, follow-up periods, primary and secondary end points, statistical analyses and confounded further...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 83
Published: 19 February 2019
10.1159/000492357
EISBN: 978-3-318-06389-9
...” designed for recurrent disease after an interval free of disease, TNM does not include patients with persistent disease. This is especially important in HPC, where local recurrence after CRT and primary surgery, has been reported to be around 40 and 15% respectively [ 39 ]. Evaluation of Recurrent...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491034
EISBN: 978-3-318-06409-4
... concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. The most common disorders include primary hyperparathyroidism (PHPT), malignancy, granulomatous diseases, and medications. PHPT is a disease characterized by excessive secretion of PTH. PHPT is most...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491035
EISBN: 978-3-318-06409-4
... Abstract Asymptomatic primary hyperparathyroidism has become the most common presentation of primary hyperparathyroidism in Europe and North America, and an increasingly common presentation in other parts of the world. As many as 25% of asymptomatic patients may develop indications...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491037
EISBN: 978-3-318-06409-4
... Abstract Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have...
Book Chapter
Series: Monographs in Oral Science
Volume: 27
Published: 24 September 2018
10.1159/000487835
EISBN: 978-3-318-06369-1
... Abstract In line with reducing the invasiveness of interventions in permanent teeth and changes towards more biological approaches, there have also been moves away from traditional restorative approaches to managing primary teeth where carious dentine/lesions were completely excised...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 50
Published: 20 April 2018
10.1159/000486076
EISBN: 978-3-318-06339-4
... Abstract Primary hyperparathyroidism (PHPT) is a common disorder of mineral metabolism characterized by hypercalcemia and incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. PHPT is most often asymptomatic, but it does increase the risk...
Book Chapter
Series: Current Problems in Dermatology
Volume: 53
Published: 13 November 2017
10.1159/000478079
EISBN: 978-3-318-06101-7
... Abstract Treatment of advanced PCLs is limited and rarely reaches complete remission despite aggressive treatment modalities, such as polychemotherapy with various adverse effects. However, several monoclonal antibodies drug agents in patients with advanced primary cutaneous lymphomas...
Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
10.1159/000443863
EISBN: 978-3-318-05840-6
... Abstract Primary adrenal hypercortisolism is mainly due to cortisol-producing adrenocortical adenomas, bilateral micronodular or macronodular disease, and adrenal carcinomas. Important advances in the pathophysiology of primary adrenal hypercortisolism have been made in the last few years...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
10.1159/000443871
EISBN: 978-3-318-05840-6
... of primary adrenocortical insufficiency (PAI) in around 80-90% of cases [ 1 ]. Autoimmune PAI is also known as autoimmune Addison's disease (AAD), after the name of the physician who in 1855 described the disease and attributed it to a pathology of the adrenal glands. In AAD, autoimmune adrenalitis...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441867
EISBN: 978-3-318-05651-8
... Abstract In the sensory hair cells of the mammalian cochlea, the primary cilia in the planar cell polarity as well as the tight junctions in the epithelial cell polarity and the barrier are important to maintain normal hearing. Temperature-sensitive mouse cochlear precursor hair cells were used...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 78
Published: 19 April 2016
10.1159/000442128
EISBN: 978-3-318-05802-4
... that are performed, including imaging and tissue biopsy. A systematic approach to ensure resection with clear margins, management of the facial nerve, applicable extensions of the primary resection and management of the neck are presented. The key determinants of disease control, including the stage (early...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 41
Published: 22 July 2015
10.1159/000381170
EISBN: 978-3-318-05457-6
... Abstract This chapter considers the pragmatic integration of frailty in primary care. While some patients present to primary care practitioners with relatively well-defined problems that can be managed by a single intervention and/or organ-specific specialist referral, others present...
Book Chapter
Series: Endocrine Development
Volume: 28
Published: 11 June 2015
10.1159/000381037
EISBN: 978-3-318-05467-5
... Abstract Primary osteoporosis in childhood encompasses a range of bone fragility conditions that typically have a genetic origin. Understanding of the pathophysiology and genetics of primary osteoporosis has increased dramatically over the past 10 years. The clinical manifestations...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 113
Published: 17 April 2015
10.1159/000367880
EISBN: 978-3-318-02691-7
... Primary malnutrition Secondary malnutrition Management Prevention Key Messages • Malnutrition is responsible for almost one third of all deaths in children <5 years of age and causes impaired intellectual capabilities among those who survive • Primary malnutrition, commonly...