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Book Chapter
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000528056
EISBN: 978-3-318-07124-5
... array of molecular size with most falling in the middle molecular weight size. Thus, they are potentially removed by hemoadsorption. In this regard, in the field of hemoadsorption in sepsis, two approaches have developed: one based on selective targeting of a key molecule (e.g., endotoxin) and the other...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519383
EISBN: 978-3-318-07015-6
... for intervention. Fig. 1. The long-term consequences of early-life adversity, some of its programming pathways, and the potential role of nutrition in modulating the effects. The Interplay between Early-Life Factors: Nutritional Interventions In this section, we will describe some of the evidence...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505031
EISBN: 978-3-318-06685-2
... microorganisms may arise from unhygienic handling as well as from the water used to clean and rinse the devices, for example. The human milk microbiota has a wide spectrum of potential uses. Most of them have been focused on the infant (including the preterm ones), but some bacterial strains present in human...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 93
Published: 26 February 2020
10.1159/000503356
EISBN: 978-3-318-06649-4
... demand for iron in erythropoiesis, as well as a potential reduction in iron intake due to reliance on complementary foods low in iron. Anemia risk is also influenced by factors including other micronutrient deficiencies, inflammation, infection, and the onset of disorders affecting red blood cell...
Book Chapter
Series: Monographs in Human Genetics
Volume: 21
Published: 11 September 2017
10.1159/000477285
EISBN: 978-3-318-06098-0
... provided options for maturing SSCs and more advanced germ cells in milieus similar to those that are present naturally. However, the advantages of these in vivo settings are limited, especially with a view to their future potential as clinical tools for fertility preservation techniques, e.g...
Book Chapter
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444975
EISBN: 978-3-318-05867-3
... Abstract MicroRNAs (miRNAs) are small noncoding RNAs that function as fundamental regulators of gene and protein expression by RNA interference. Currently, miRNAs are being investigated as diagnostic and prognostic markers as well as potential therapeutic targets in transplantation...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444976
EISBN: 978-3-318-05867-3
... they can be generated from the patient's own somatic cells through various reprogramming techniques, iPSCs have great potential in disease modeling, drug screening, regenerative medicine, and cell therapy. Vascularized composite allotransplantation (VCA) differs from organ transplantation involving...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 115
Published: 24 May 2016
10.1159/000442072
EISBN: 978-3-318-05685-3
... lunches (the rest paid full price). Along with free food, the federal government gave schools over USD 11 billion in 2012 to reimburse them for the cost of providing these meals. Eligibility for the NSLP begins at the individual level, insofar as any child at a participating school is potentially...
Book Chapter
Series: Monographs in Human Genetics
Volume: 20
Published: 26 April 2016
10.1159/000444570
EISBN: 978-3-318-05856-7
... reported in mouse models of HL will establish a framework for developing gene replacement therapies in humans. Here, we review the most recent advances in cochlear gene therapy. This review will cover the animal models used in these studies, the most widely employed viral vectors, potential routes...
Book Chapter
Series: Contributions to Nephrology
Volume: 187
Published: 12 February 2016
10.1159/000442365
EISBN: 978-3-318-05826-0
..., and 5/6th nephrectomy have served as paradigms of the early mechanism and pathology of AKI and how the early events may eventually cause the advanced interstitial fibrosis that is characteristic of progression to CKD. Furthermore, these models provide opportunities to explore potentially promising...
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000438954
EISBN: 978-3-318-05565-8
... reduce A2E levels and directly reduce the toxic effects of A2E on the RPE, potentially reducing loss of photoreceptor function and density, and slowing clinical progression of decreased visual acuity and scotoma formation [ 23 ]. Emixustat is the first drug to be studied in single- and multiple-dose...
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000438953
EISBN: 978-3-318-05565-8
... therapies are currently under consideration for the aforementioned disorders. In the following section, agents targeting platelet-derived growth factors (PDGF) are discussed as a potential therapeutic option for retinochoroidal vascular diseases. PDGF play an important role in the angiogenesis cascade...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 30
Published: 28 September 2015
10.1159/000435934
EISBN: 978-3-318-05574-0
... Abstract The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for capsaicin. Peripheral TRPV1 has a very well-described role...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381581
EISBN: 978-3-318-05474-3
... of a biosimilar product, no assessments of similarity will be necessary. This may lead at the end to a situation in which biosimilars may become standalone products, as the overlap between activities is reduced (fig. 1 ). Fig. 1 Potential impact of manufacturing changes on biosimilars (adapted from P...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 101
Published: 21 May 2015
10.1159/000371697
EISBN: 978-3-318-02341-1
... showed SLIT followed by OIT is more effective than SLIT alone is in achieving desensitization. This combination therapy (SLIT and OIT) may benefit from the safety of SLIT and the potential for achieving higher doses of food with OIT. Anti-IgE Monoclonal Antibodies (Omalizumab) for Food Allergy...
Book Chapter
Book Chapter
Series: Developments in Ophthalmology
Volume: 54
Published: 27 August 2014
10.1159/000360444
EISBN: 978-3-318-02661-0
... in terms of equipment expense could be seen for easy and uncomplicated cases. Other companies recognized this weakness of Accurus and the potential in developing a more customizable approach to this type of surgery. Synergetics USA Inc. developed a Venturi pump-based vitrectomy system with fluidics...
Book Chapter
Series: Monographs in Oral Science
Volume: 25
Published: 24 June 2014
10.1159/000360372
EISBN: 978-3-318-02553-8
... of the saliva components as well as of the acquired dental pellicle can serve as potential biomarkers for dental erosion. The biological factors related to dental erosion involve properties and characteristics of saliva, acquired dental pellicle, tooth structure and surrounding soft tissues [ 1 , 2...